Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 2/20 | 0.54 |
| ▸ | RXRB | P28702 | 2/20 | 0.54 |
| ▸ | RXRG | P48443 | 2/20 | 0.54 |
| ▸ | THRA | P10827 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | S1PR3 | Q99500 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CTSS | P25774 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 1/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 6/20 | 0.41 |
| ▸ | S1PR5 | Q9H228 | 3/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28035311 | 0.89 | THRA (0.46) | RXRARXRBRXRGTHRATHRB | |
| SCHEMBL403300 | 0.84 | RXRA (0.58) | RXRARXRBRXRGS1PR3KMT2A | |
| SCHEMBL17386570 | 0.84 | RXRA (0.54) | RXRARXRBRXRGS1PR3MEN1 | |
| SCHEMBL30440283 | 0.84 | RXRA (0.54) | RXRARXRBRXRGS1PR3MEN1 | |
| SCHEMBL17664021 | 0.82 | RXRA (0.53) | RXRARXRBRXRGS1PR3MEN1 | |
| SCHEMBL24860963 | 0.81 | NOTUM (0.60) | RXRARXRBRXRGS1PR3MEN1 | |
| SCHEMBL402684 | 0.81 | RXRA (0.52) | RXRARXRBRXRGS1PR3MEN1 | |
| SCHEMBL25139472 | 0.81 | KCNQ3 (0.50) | THRATHRBMEN1KMT2APDE4B | |
| SCHEMBL28035821 | 0.80 | THRA (0.61) | RXRARXRBRXRGTHRATHRB | |
| SCHEMBL28162947 | 0.79 | PDE4B (0.47) | THRATHRBMEN1KMT2APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106414438-A | 2-acylaminothiazole derivative or salt thereof | 安斯泰来制药株式会社 | 2017-02-15 | — | — | CN | disclosed |
| CN-105008353-A | 2-acylaminothiazole derivative or salt thereof | ASTELLAS PHARMA INC | 2015-10-28 | — | — | CN | disclosed |