Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Naphthalene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 4/20 | 0.54 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.53 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.53 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA4 | P22748 | 1/20 | 0.35 |
| ▸ | CA5A | P35218 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ALPG | P10696 | 1/20 | 0.35 |
| ▸ | NPY1R | P25929 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NPY2R | P49146 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Naphthalene SCHEMBL31244378 | 0.93 | CYP2A6 (0.53) | GPR84CYP2A6ALOX12PTPN1LMNA | |
| Naphthalene SCHEMBL30716582 | 0.88 | GPR84 (0.50) | GPR84CYP2A6ALOX12PTPN1LMNA | |
| Naphthalene SCHEMBL28237204 | 0.88 | GPR84 (0.50) | GPR84CYP2A6ALOX12PTPN1LMNA | |
| Naphthalene SCHEMBL28077853 | 0.85 | GPR84 (0.54) | GPR84CYP2A6ALOX12PTPN1LMNA | |
| Anthracene SCHEMBL28420553 | 0.81 | GPR84 (0.50) | GPR84CYP2A6ALOX12PTPN1LMNA | |
| Biphenyl SCHEMBL11127740 | 0.78 | ALDH1A1 (0.56) | PTPN1LMNAALDH1A1HSD17B10TDP1 | |
| Naphthalene SCHEMBL30445823 | 0.76 | CYP2A6 (0.57) | CYP2A6ALOX12PTPN1L3MBTL1CA2 | |
| Naphthalene SCHEMBL1680172 | 0.76 | CYP2A6 (0.57) | CYP2A6ALOX12PTPN1L3MBTL1CA2 | |
| Naphthalene SCHEMBL19062554 | 0.76 | CYP2A6 (0.57) | CYP2A6ALOX12PTPN1L3MBTL1CA2 | |
| Naphthalene SCHEMBL30423233 | 0.76 | CYP2A6 (0.57) | CYP2A6ALOX12PTPN1L3MBTL1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105293913-A | Celadon glaze and manufacturing method thereof | LONGQUAN JINHONG CERAMICS INDUSTRY CO LTD | 2016-02-03 | — | — | CN | claimed |
| CN-105036558-A | Micro-nano composite glaze material | LONGQUAN JINHONG PORCELAIN INDUSTRY CO LTD | 2015-11-11 | — | — | CN | claimed |
| CN-119064333-A | Fluorescence detection method for alkaline phosphatase activity and application | 曲阜师范大学 | 2024-12-03 | — | — | CN | disclosed |
| CN-115078579-B | Application of naphthyl-modified magnetic ferroferric oxide nano extraction material in enrichment and detection of polycyclic aromatic hydrocarbon | 湖北省农业科学院农业质量标准与检测技术研究所 | 2023-05-16 | — | — | CN | disclosed |
| CN-114957627-A | Preparation method of polyester with low byproduct tetrahydrofuran | 万华化学集团股份有限公司 | 2022-08-30 | — | — | CN | disclosed |
| CN-105277523-B | A kind of amphipathic Eu (III) complex and its application in detection cytidine triphosphate | 陕西师范大学 | 2018-12-28 | — | — | CN | disclosed |
| CN-107868166-A | Modified acrylate emulsion for eliminating formaldehyde in air and preparation method thereof | 佛山市顺德区巴德富实业有限公司 | 2018-04-03 | — | — | CN | disclosed |
| CN-105293913-A | Celadon glaze and manufacturing method thereof | LONGQUAN JINHONG CERAMICS INDUSTRY CO LTD | 2016-02-03 | — | — | CN | disclosed |
| CN-105277523-A | Amphipathic Eu (III) complex and application thereof in detection for cytidine triphosphate | UNIV SHAANXI NORMAL | 2016-01-27 | — | — | CN | disclosed |
| CN-105036558-A | Micro-nano composite glaze material | LONGQUAN JINHONG PORCELAIN INDUSTRY CO LTD | 2015-11-11 | — | — | CN | disclosed |