Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.51 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 3/20 | 0.41 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.40 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.40 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.40 |
| ▸ | IKBKB | O14920 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10719764 | 0.79 | NOTUM (0.49) | NOTUMRIPK2MAPK1SMN1; SMN2HSD17B10 | |
| SCHEMBL27777814 | 0.78 | PARP1 (0.50) | NOTUMRIPK2SMN1; SMN2HSD17B10KDM4E | |
| SCHEMBL4783773 | 0.77 | NOTUM (0.47) | NOTUMRIPK2MAPK1SMN1; SMN2HSD17B10 | |
| SCHEMBL3433959 | 0.75 | NOTUM (0.49) | NOTUMRIPK2MAPK1SMN1; SMN2HSD17B10 | |
| SCHEMBL1396731 | 0.73 | MAPK1 (0.58) | NOTUMRIPK2MAPK1SMN1; SMN2HSD17B10 | |
| SCHEMBL27712881 | 0.72 | SMN1; SMN2 (0.47) | NOTUMSMN1; SMN2TSHRDDB1CRBN | |
| Hydrochloric Acid SCHEMBL29908833 | 0.71 | MAPK1 (0.56) | NOTUMRIPK2MAPK1SMN1; SMN2HSD17B10 | |
| SCHEMBL21812530 | 0.71 | ALDH1A1 (0.49) | NOTUMRIPK2MAPK1SMN1; SMN2HSD17B10 | |
| SCHEMBL13506760 | 0.69 | ATM (0.46) | NOTUMMAPK1SMN1; SMN2HSD17B10KDM4E | |
| SCHEMBL11453643 | 0.69 | NOTUM (0.65) | NOTUMSMN1; SMN2HSD17B10KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105164113-A | Pyrroloamide inhibitors | ABBVIE INC | 2015-12-16 | — | — | CN | claimed |
| CN-105164113-A | Pyrroloamide inhibitors | ABBVIE INC | 2015-12-16 | — | — | CN | disclosed |