Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | COMT | P21964 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.36 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.35 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.35 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28037281 | 0.75 | NOTUM (0.51) | NOTUMMAPK1SMN1; SMN2RIPK2MEN1 | |
| SCHEMBL10719764 | 0.72 | NOTUM (0.49) | NOTUMMAPK1SMN1; SMN2RIPK2MEN1 | |
| SCHEMBL8506114 | 0.71 | ATM (0.43) | NOTUMSMN1; SMN2MEN1KMT2ACOMT | |
| SCHEMBL4783773 | 0.71 | NOTUM (0.47) | NOTUMMAPK1SMN1; SMN2RIPK2PARP1 | |
| SCHEMBL8505536 | 0.68 | PTGS2 (0.39) | NOTUMSMN1; SMN2COMTDDB1CRBN | |
| SCHEMBL8634801 | 0.67 | ATM (0.46) | NOTUMSMN1; SMN2MEN1KMT2ACOMT | |
| SCHEMBL1396731 | 0.67 | MAPK1 (0.58) | NOTUMMAPK1SMN1; SMN2RIPK2PARP1 | |
| SCHEMBL27944336 | 0.67 | NOTUM (0.50) | NOTUMMAPK1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL3260482 | 0.66 | NOTUM (1.00) | NOTUMMAPK1MEN1KMT2ACOMT | |
| Hydrochloric Acid SCHEMBL29908833 | 0.66 | MAPK1 (0.56) | NOTUMMAPK1SMN1; SMN2RIPK2PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010042626-A1 | 1-PHENYLPYRROLE COMPOUNDS | EXELIXIS, INC. (US) | 2010-04-15 | — | — | WO | disclosed |