Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 2/20 | 0.38 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.37 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.37 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30038558 | 0.80 | MEN1 (0.51) | NOTUMSMN1; SMN2MAPTPOLBKDM4E | |
| SCHEMBL28037281 | 0.77 | NOTUM (0.51) | NOTUMSMN1; SMN2MAPTPOLBMAPK1 | |
| Trifluoroacetic Acid SCHEMBL28285384 | 0.77 | NOTUM (0.42) | NOTUMSMN1; SMN2MAPTPOLBMAPK1 | |
| SCHEMBL9837450 | 0.77 | MAPK1 (0.43) | SMN1; SMN2MAPTPOLBMAPK1KDM4E | |
| SCHEMBL10719764 | 0.75 | NOTUM (0.49) | NOTUMSMN1; SMN2MAPTMAPK1KDM4E | |
| SCHEMBL10364977 | 0.73 | MAPT (0.78) | SMN1; SMN2MAPTPOLBMAPK1KDM4E | |
| SCHEMBL29843451 | 0.73 | FGFR1 (0.46) | SMN1; SMN2MAPTPOLBKDM4EALDH1A1 | |
| SCHEMBL28267150 | 0.72 | MAPK1 (0.50) | NOTUMSMN1; SMN2MAPTMAPK1KDM4E | |
| SCHEMBL3433959 | 0.71 | NOTUM (0.49) | NOTUMSMN1; SMN2MAPTMAPK1KDM4E | |
| SCHEMBL1396731 | 0.69 | MAPK1 (0.58) | NOTUMSMN1; SMN2MAPTPOLBMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773768-A4 | PYRROLE DERIVATIVES AS PHARMACEUTICAL AGENTS | EXELIXIS INC (US) | 2008-08-06 | — | — | EP | claimed |
| EP-1773768-A2 | PYRROLE DERIVATIVES AS PHARMACEUTICAL AGENTS | Exelixis, Inc. (US) | 2007-04-18 | — | — | EP | claimed |
| WO-2006012642-A2 | PYRROLE DERIVATIVES AS PHARMACEUTICAL AGENTS | EXELIXIS, INC. (US) | 2006-02-02 | — | — | WO | claimed |
| EP-4317133-B1 | CRYSTALLINE FORM OF PYRROLE AMIDE COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF | SUNSHINE LAKE PHARMA CO LTD (CN) | 2026-04-15 | — | — | EP | disclosed |
| EP-4317133-A1 | CRYSTALLINE FORM OF PYRROLE AMIDE COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF | Sunshine Lake Pharma Co., Ltd. (CN) | 2024-02-07 | — | — | EP | disclosed |
| WO-2022228215-A1 | PREPARATION METHOD FOR PYRROLE AMIDE COMPOUND | 广东东阳光药业有限公司 | 2022-11-03 | — | — | WO | disclosed |
| WO-2022206666-A1 | CRYSTALLINE FORM OF PYRROLE AMIDE COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF | 广东东阳光药业有限公司 | 2022-10-06 | — | — | WO | disclosed |