Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.38 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.38 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.38 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.36 |
| ▸ | PRNP | P04156 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.36 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.35 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.35 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.35 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.35 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ammonia Solution, Strong SCHEMBL2248291 | 0.82 | PTGES (0.44) | PTGESSMN1; SMN2GABRA1GABRG2GABRB3 | |
| Ammonia Solution, Strong SCHEMBL2248963 | 0.82 | SMN1; SMN2 (0.56) | PTGESSMN1; SMN2GABRA1GABRG2GABRB3 | |
| SCHEMBL27769710 | 0.78 | PTGES (0.45) | PTGESSMN1; SMN2GABRA1GABRG2GABRB3 | |
| SCHEMBL28038007 | 0.77 | ALK (0.46) | RXFP1PRNPPPARGNR2E3NCOR2 | |
| SCHEMBL17578990 | 0.77 | ALK (0.43) | SMN1; SMN2GABRA1GABRG2GABRB3GABRA5 | |
| Hydrochloric Acid SCHEMBL27996151 | 0.76 | ALK (0.42) | SMN1; SMN2GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL28140818 | 0.74 | SMN1; SMN2 (0.44) | PTGESSMN1; SMN2ALKHTTLMNA | |
| SCHEMBL16224287 | 0.72 | BCHE (0.45) | SMN1; SMN2GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL1557613 | 0.69 | TNF (0.42) | SMN1; SMN2GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL20073053 | 0.69 | HTT (0.49) | SMN1; SMN2GABRA1GABRG2GABRB3GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105143228-B | [1,2,4] triazol [4,3 a] pyridine derivatives, its preparation method or its in application pharmaceutically | 江苏豪森药业集团有限公司 | 2017-07-21 | — | — | CN | disclosed |
| CN-105143228-A | [1,2,4]triazol[4,3-a]pyridine derivate, preparation method therefor or medical application thereof | JIANGSU HANSOH PHARMACEUTICAL | 2015-12-09 | — | — | CN | disclosed |