Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Glycine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLRA1 | P23415 | 1/20 | 0.46 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.46 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.46 |
| ▸ | CTH | P32929 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.32 |
| ▸ | BLM | P54132 | 3/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | THRB | P10828 | 2/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.32 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.32 |
| ▸ | GABRP | O00591 | 1/20 | 0.32 |
| ▸ | GABRD | O14764 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.32 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL94899 | 0.83 | — | — | |
| Hydrochloric Acid SCHEMBL9443697 | 0.80 | — | — | |
| Water SCHEMBL6141043 | 0.80 | — | — | |
| Glycine SCHEMBL27759657 | 0.77 | GLRA1 (0.46) | GLRA1SLC6A9OR51E2GABRR1KMT2A | |
| Vinyl Ether SCHEMBL5600513 | 0.75 | GLRA1 (0.56) | GLRA1SLC6A9OR51E2CTHLMNA | |
| Glycine SCHEMBL9640004 | 0.74 | GLRA1 (0.83) | GLRA1SLC6A9OR51E2CTHLMNA | |
| Glycine SCHEMBL28658007 | 0.74 | GLRA1 (0.83) | GLRA1SLC6A9OR51E2CTHLMNA | |
| Glycine SCHEMBL3204478 | 0.74 | GLRA1 (0.83) | GLRA1SLC6A9OR51E2CTHLMNA | |
| Glycine SCHEMBL6386791 | 0.74 | — | — | |
| SCHEMBL634237 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103621507-B | Herbicidal combinations containing 2-(quinoline-8-yl) carbonyl-cyclohexane-1,3-cyclohexadione compounds and application thereof | BEIJING FAGAIYIN TECHNOLOGY CO.,LTD. (CN) | 2015-10-07 | — | — | CN | disclosed |