Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Glycine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLRA1 | P23415 | 1/20 | 0.46 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.46 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.46 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.31 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
| ▸ | BLM | P54132 | 1/20 | 0.30 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL28785631 | 0.85 | — | — | |
| Malonic Acid SCHEMBL5779578 | 0.84 | LDHA (0.43) | FFAR3ALDH1A1TSHRALOX15HCAR2 | |
| Urea SCHEMBL27407445 | 0.83 | — | — | |
| Acetic Acid SCHEMBL6676468 | 0.83 | — | — | |
| Acrylic Acid SCHEMBL28659504 | 0.81 | LMNA (0.50) | FFAR3ALDH1A1TSHRALOX15HCAR2 | |
| Acetoacetic Acid SCHEMBL27563882 | 0.81 | KDM4E (0.34) | ALDH1A1ALOX15CYP2D6SMN1; SMN2 | |
| SCHEMBL29906502 | 0.80 | PTGS1 (0.42) | FFAR3ALDH1A1TSHRHCAR2 | |
| Maleic Acid SCHEMBL5854822 | 0.79 | HCAR2 (0.52) | ALDH1A1TSHRHCAR2SMN1; SMN2 | |
| Fumaric Acid SCHEMBL718708 | 0.79 | HCAR2 (0.52) | ALDH1A1TSHRHCAR2SMN1; SMN2 | |
| Fumaric Acid SCHEMBL28225492 | 0.79 | HCAR2 (0.52) | ALDH1A1TSHRHCAR2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103621507-A | Weeding compositions containing 2-(quinoline-8-yl)carbonyl-cyclohexane-1,3-dione compounds and application of weeding compositions | BEIJING FAGAIYIN TECHNOLOGY CO LTD | 2014-03-12 | — | — | CN | disclosed |
| CN-101420852-A | Herbicidal mixtures | DU PONT (US) | 2009-04-29 | — | — | CN | disclosed |