Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESRRA | P11474 | 4/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 2/20 | 0.45 |
| ▸ | CA2 | P00918 | 2/20 | 0.45 |
| ▸ | CA4 | P22748 | 2/20 | 0.45 |
| ▸ | CA9 | Q16790 | 2/20 | 0.45 |
| ▸ | HPGDS | O60760 | 1/20 | 0.44 |
| ▸ | ALKBH2 | Q6NS38 | 1/20 | 0.44 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | MIF | P14174 | 1/20 | 0.44 |
| ▸ | TPMT | P51580 | 1/20 | 0.43 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL69876 | 0.85 | ESRRA (0.62) | ESRRAL3MBTL1CA1CA2CA4 | |
| SCHEMBL28801446 | 0.83 | ESRRA (0.60) | ESRRAL3MBTL1CA1CA2CA4 | |
| SCHEMBL69165 | 0.81 | ESRRA (0.64) | ESRRACA1CA2CA9MAOA | |
| SCHEMBL3477570 | 0.81 | CA1 (0.57) | ESRRAL3MBTL1POLBCA1CA2 | |
| SCHEMBL27498827 | 0.79 | CYP2C9 (0.47) | L3MBTL1HPGDSALKBH2TPMTKMT2A | |
| SCHEMBL27575419 | 0.77 | ALKBH2 (0.77) | HPGDSALKBH2KMT2A | |
| SCHEMBL31734379 | 0.77 | HPGDS (0.57) | ESRRAL3MBTL1CA1CA2CA4 | |
| SCHEMBL1749529 | 0.76 | OGT (0.53) | ESRRACA1CA2CA4CA9 | |
| SCHEMBL28167460 | 0.76 | NOTUM (0.53) | L3MBTL1POLBHPGDSALKBH2NOTUM | |
| SCHEMBL23889183 | 0.76 | ESRRA (0.59) | ESRRAL3MBTL1CA1CA2CA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105073741-A | Phthalazinones and isoquinolinones as rock inhibitors | BRISTOL MYERS SQUIBB CO | 2015-11-18 | — | — | CN | disclosed |