Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K4 | P45985 | 13/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.49 |
| ▸ | MAPK6 | Q16659 | 2/20 | 0.49 |
| ▸ | MAP2K7 | O14733 | 2/20 | 0.42 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.41 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.41 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.40 |
| ▸ | ITK | Q08881 | 3/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27677673 | 0.88 | MAP2K4 (0.42) | MAP2K4MAPK1MAPK6AMY1AITK | |
| SCHEMBL28776088 | 0.82 | DYRK1A (0.57) | GSK3B | |
| SCHEMBL6612570 | 0.82 | MAP2K4 (0.51) | MAP2K4MAPK1AMY1AGSK3B | |
| SCHEMBL1573919 | 0.78 | HRH4 (0.47) | MAP2K4MAPK1MAPK6HTR2A | |
| SCHEMBL1574410 | 0.78 | MAP2K4 (0.46) | MAP2K4MAPK1MAPK6 | |
| SCHEMBL5820415 | 0.78 | KDM4E (0.53) | MAP2K4GSK3B | |
| SCHEMBL1573862 | 0.77 | ALDH1A1 (0.44) | MAP2K4MAPK1MAPK6HTR2A | |
| SCHEMBL1573971 | 0.77 | MAP2K4 (0.42) | MAP2K4MAPK1MAPK6GSK3BHTR2A | |
| SCHEMBL1573835 | 0.76 | GAA (0.45) | MAP2K4MAPK1MAPK6HTR2A | |
| SCHEMBL1573879 | 0.75 | MAP2K4 (0.41) | MAP2K4MAPK1MAPK6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105073741-A | Phthalazinones and isoquinolinones as rock inhibitors | BRISTOL MYERS SQUIBB CO | 2015-11-18 | — | — | CN | disclosed |