Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K4 | P45985 | 6/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.43 |
| ▸ | LIPE | Q05469 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28039585 | 0.78 | MAP2K4 (0.51) | MAP2K4MAPK1MAPK6 | |
| SCHEMBL1574085 | 0.70 | ALOX15 (0.54) | MAP2K4MAPK1SMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL1573919 | 0.69 | HRH4 (0.47) | MAP2K4MAPK1MAPK6ALDH1A1 | |
| SCHEMBL4843722 | 0.69 | KIT (0.41) | MAP2K4MAPK1MAPK6SMN1; SMN2KDM4E | |
| SCHEMBL1574118 | 0.68 | FLT3 (0.47) | MAPK1SMN1; SMN2RAB9ANPC1MEN1 | |
| SCHEMBL1573862 | 0.68 | ALDH1A1 (0.44) | MAP2K4MAPK1MAPK6SMN1; SMN2HTT | |
| SCHEMBL1573971 | 0.68 | MAP2K4 (0.42) | MAP2K4MAPK1MAPK6SMN1; SMN2ALDH1A1 | |
| SCHEMBL30847603 | 0.68 | SMN1; SMN2 (0.60) | LIPESMN1; SMN2KDM4EL3MBTL1LMNA | |
| SCHEMBL1573980 | 0.68 | ROCK1 (0.41) | MAP2K4MAPK1MAPK6L3MBTL1 | |
| SCHEMBL1574020 | 0.68 | L3MBTL1 (0.47) | LIPESMN1; SMN2L3MBTL1RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1713779-B1 | INDAZOLE DERIVATIVES AS INHIBITORS OF HORMONE-SENSITIVE LIPASES | SANOFI AVENTIS DEUTSCHLAND (DE) | 2011-04-13 | — | — | EP | disclosed |