Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.32 |
| ▸ | MAPT | P10636 | 4/20 | 0.32 |
| ▸ | HTT | P42858 | 4/20 | 0.32 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16501134 | 0.68 | LMNA (0.38) | ADRA2AADRA2BADRA2CLMNAPOLB | |
| SCHEMBL29293394 | 0.66 | POLB (0.33) | ADRA2AADRA2BADRA2CLMNAPOLB | |
| SCHEMBL21850711 | 0.64 | MAPT (0.38) | LMNAPOLBKDM4EGAAKMT2A | |
| SCHEMBL16079591 | 0.64 | LMNA (0.34) | LMNAPOLBKDM4EKMT2AMAPT | |
| SCHEMBL16079593 | 0.64 | LMNA (0.34) | LMNAPOLBKDM4EGAAKMT2A | |
| SCHEMBL5030624 | 0.64 | GAA (0.38) | ADRA2AADRA2BADRA2CLMNAPOLB | |
| SCHEMBL14087874 | 0.62 | MAPT (0.34) | LMNAKDM4EGAAKMT2AMAPT | |
| SCHEMBL14415427 | 0.61 | LMNA (0.35) | LMNAPOLBKDM4EGAAKMT2A | |
| SCHEMBL27793746 | 0.61 | LMNA (0.43) | ADRA2AADRA2BADRA2CLMNAPOLB | |
| SCHEMBL6276533 | 0.59 | LMNA (0.36) | ADRA2AADRA2BADRA2CLMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105085515-B | Hydrazide kind compound as coagulation factor xa inhibitors | 华北制药股份有限公司 | 2019-02-01 | — | — | CN | claimed |
| CN-105085515-B | Hydrazide kind compound as coagulation factor xa inhibitors | 华北制药股份有限公司 | 2019-02-01 | — | — | CN | disclosed |
| CN-105026392-B | 4,5-dihydro-pyrazolo [3, 4-c] pyrid-2-ones, preparation method and application thereof | 四川海思科制药有限公司 | 2017-05-10 | — | — | CN | disclosed |
| CN-105085515-A | Hydrazide compound as blood coagulation factor Xa inhibitor | NANJING MINGDE NEW DRUG RES AND DEV CO LTD | 2015-11-25 | — | — | CN | disclosed |