Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | ELANE | P08246 | 1/20 | 0.32 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | KMO | O15229 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5492690 | 0.81 | KDM4E (0.30) | MAPTALDH1A1KDM4EHSD17B10MAPK1 | |
| SCHEMBL3469383 | 0.79 | ALDH1A1 (0.31) | LMNAALDH1A1 | |
| SCHEMBL752178 | 0.76 | ALDH1A1 (0.34) | MAPTALDH1A1KMT2ACYP1A2KDM4E | |
| SCHEMBL16501134 | 0.73 | LMNA (0.38) | LMNAPOLBMAPTALDH1A1MEN1 | |
| SCHEMBL1993537 | 0.68 | LMNA (0.36) | LMNAPOLBMAPTALDH1A1MEN1 | |
| SCHEMBL31560438 | 0.68 | LMNA (0.36) | LMNAPOLBMAPTALDH1A1MEN1 | |
| SCHEMBL14940618 | 0.66 | POLB (0.45) | LMNAPOLBALDH1A1MEN1KMT2A | |
| SCHEMBL3376203 | 0.66 | HPGD (0.45) | POLBMAPTHTTKMT2ANPC1 | |
| SCHEMBL14087798 | 0.64 | KDM4E (0.33) | LMNAPOLBMAPTALDH1A1MEN1 | |
| SCHEMBL5181001 | 0.64 | KDM4E (0.33) | LMNAPOLBMAPTALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005061462-A2 | DIARYL PYRAZOLE DERIVATIVES AND THEIR USE AS NEUROKININ-3 RECEPTOR MODULATORS | NEUROGEN CORPORATION (US) | 2005-07-07 | — | — | WO | disclosed |