SCHEMBL28040367

SCHEMBL28040367

CCCCC1=CC=C[C]1[Si](C)(c1ccccc1)c1ccccc1

nearest known ligand 0.39

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
HSD11B1 P28845 2/20 0.35
POLB P06746 1/20 0.31
PARP1 P09874 1/20 0.31
TLR8 Q9NR97 2/20 0.30
TLR7 Q9NYK1 1/20 0.30
CNR1 P21554 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28040369 0.90 KDM4E (0.33)
SCHEMBL28040355 0.88 ESR1 (0.33) HSD11B1POLBPARP1TLR8TLR7
SCHEMBL27870084 0.86 HSD11B1 (0.33) HSD11B1POLBPARP1CNR1
SCHEMBL28800428 0.85 HSD11B1 (0.31) HSD11B1POLB
SCHEMBL27953398 0.83 HSD11B1 (0.31) HSD11B1POLBPARP1
SCHEMBL27886312 0.78 CNR1 (0.31) TLR7CNR1
SCHEMBL28040849 0.78 ESR1 (0.35)
SCHEMBL27886271 0.76 KDM4E (0.33)
SCHEMBL27886295 0.75 KDM4E (0.31)
SCHEMBL27953349 0.73 KDM4E (0.32)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-102666561-B Transition metal complex, the cyclopentadiene compound of catalyst for trimerization and replacement SUMITOMO CHEMICAL CO.,LTD. (JP) 2015-11-25 CN disclosed