Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.53 |
| ▸ | TSHR | P16473 | 3/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.45 |
| ▸ | PDE2A | O00408 | 1/20 | 0.45 |
| ▸ | PDE5A | O76074 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | APEX1 | P27695 | 1/20 | 0.45 |
| ▸ | PDE4A | P27815 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.45 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.45 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL502270 | 0.85 | CYP1A2 (0.64) | ALDH1A1TDP1TSHRCYP3A4LMNA | |
| SCHEMBL6405854 | 0.84 | ALDH1A1 (0.50) | ALDH1A1TDP1TSHRCYP3A4LMNA | |
| SCHEMBL28854014 | 0.83 | CYP3A4 (0.49) | ALDH1A1TDP1TSHRCYP3A4LMNA | |
| SCHEMBL4002644 | 0.82 | GAA (0.54) | ALDH1A1TDP1TSHRMAPTCYP1A2 | |
| SCHEMBL4658055 | 0.82 | CYP3A4 (0.47) | ALDH1A1TDP1TSHRCYP3A4LMNA | |
| SCHEMBL502591 | 0.81 | PDGFRB (0.53) | ALDH1A1TDP1TSHRCYP3A4LMNA | |
| SCHEMBL28040574 | 0.81 | KMT2A (0.55) | ALDH1A1LMNAMAPTCYP1A2KMT2A | |
| SCHEMBL3723235 | 0.81 | ALDH1A1 (0.50) | ALDH1A1TDP1TSHRCYP3A4LMNA | |
| SCHEMBL6890955 | 0.80 | ALDH1A1 (0.56) | ALDH1A1TSHRCYP3A4CYP1A2PLA2G2A | |
| SCHEMBL6206215 | 0.80 | ALDH1A1 (0.60) | ALDH1A1TDP1TSHRCYP3A4LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105228982-B | 3-acetylamino-1- (phenyl-heteroaryl-aminocarbonyl or phenyl-heteroaryl-carbonylamino) benzene derivatives for the treatment of hyperproliferative disorders | 拜耳制药股份公司 | 2018-03-27 | — | — | CN | disclosed |
| CN-105579457-B | Substituted N-biphenyl-3-acetylamino-benzamides and N- [3- (acetylamino) phenyl ] -biphenyl-carboxamides and their use as WNT signaling pathway inhibitors | 拜耳制药股份公司 | 2017-08-04 | — | — | CN | disclosed |
| CN-105579457-A | Substituted N-biphenyl-3-acetylamino-benzamides and N- [3- (acetylamino) phenyl ] -biphenyl-carboxamides and their use as WNT signaling pathway inhibitors | Bayer Pharma AG | 2016-05-11 | — | — | CN | disclosed |
| CN-105228982-A | 3-acetylamino-1- (phenyl-heteroaryl-aminocarbonyl or phenyl-heteroaryl-carbonylamino) benzene derivatives for the treatment of hyperproliferative disorders | Bayer Pharma AG | 2016-01-06 | — | — | CN | disclosed |