Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 1/20 | 0.44 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4477360 | 0.83 | AKR1C3 (0.44) | AKR1C3AKR1C2CYP1A2KMT2AHTT | |
| SCHEMBL8166240 | 0.83 | TDP1 (0.43) | AKR1C3AKR1C2CYP1A2KMT2AHTT | |
| SCHEMBL10562329 | 0.77 | FFAR4 (0.45) | MAPTPTGDR2EPHX2 | |
| SCHEMBL28215299 | 0.77 | MAPK8 (0.41) | EPHX2 | |
| SCHEMBL3723235 | 0.77 | ALDH1A1 (0.50) | CYP1A2KMT2AHTTMEN1MAPT | |
| SCHEMBL8163363 | 0.77 | NPBWR1 (0.44) | AKR1C3AKR1C2CYP1A2KMT2AHTT | |
| SCHEMBL9367150 | 0.76 | AKR1C3 (0.50) | AKR1C3AKR1C2KMT2AHTTMEN1 | |
| SCHEMBL8431994 | 0.75 | GPR35 (0.51) | AKR1C3AKR1C2KMT2AHTTMEN1 | |
| SCHEMBL31721280 | 0.75 | GPR35 (0.51) | AKR1C3AKR1C2KMT2AHTTMEN1 | |
| SCHEMBL4002644 | 0.75 | GAA (0.54) | CYP1A2KMT2AMEN1MAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105228982-B | 3-acetylamino-1- (phenyl-heteroaryl-aminocarbonyl or phenyl-heteroaryl-carbonylamino) benzene derivatives for the treatment of hyperproliferative disorders | 拜耳制药股份公司 | 2018-03-27 | — | — | CN | disclosed |
| CN-105579457-B | Substituted N-biphenyl-3-acetylamino-benzamides and N- [3- (acetylamino) phenyl ] -biphenyl-carboxamides and their use as WNT signaling pathway inhibitors | 拜耳制药股份公司 | 2017-08-04 | — | — | CN | disclosed |
| CN-106459072-A | Inhibitors of the Wnt signaling pathway | 拜耳制药股份公司 | 2017-02-22 | — | — | CN | disclosed |
| CN-105579457-A | Substituted N-biphenyl-3-acetylamino-benzamides and N- [3- (acetylamino) phenyl ] -biphenyl-carboxamides and their use as WNT signaling pathway inhibitors | Bayer Pharma AG | 2016-05-11 | — | — | CN | disclosed |
| CN-105228982-A | 3-acetylamino-1- (phenyl-heteroaryl-aminocarbonyl or phenyl-heteroaryl-carbonylamino) benzene derivatives for the treatment of hyperproliferative disorders | Bayer Pharma AG | 2016-01-06 | — | — | CN | disclosed |