Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGAM | O43451 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | SI | P14410 | 2/20 | 0.43 |
| ▸ | MGAM2 | Q2M2H8 | 2/20 | 0.43 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.32 |
| ▸ | GABRR2 | P28476 | 2/20 | 0.32 |
| ▸ | BLM | P54132 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | APEX1 | P27695 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27351821 | 0.82 | MGAM (0.50) | MGAMGAASIMGAM2TSHR | |
| SCHEMBL11547161 | 0.82 | MGAM (0.44) | MGAMGAASIMGAM2LMNA | |
| SCHEMBL27984239 | 0.80 | MGAM (0.43) | MGAMGAASIMGAM2TDP1 | |
| SCHEMBL27657768 | 0.80 | MGAM (0.43) | MGAMGAASIMGAM2 | |
| SCHEMBL6445001 | 0.79 | MGAM (0.46) | MGAMGAASIMGAM2TSHR | |
| SCHEMBL6444996 | 0.79 | MGAM (0.46) | MGAMGAASIMGAM2TSHR | |
| SCHEMBL5227698 | 0.79 | MGAM (0.46) | MGAMGAASIMGAM2 | |
| SCHEMBL5953627 | 0.79 | — | — | |
| SCHEMBL28070896 | 0.78 | MGAM (0.41) | MGAMGAASIMGAM2TSHR | |
| SCHEMBL9068329 | 0.78 | MGAM (0.44) | MGAMGAASIMGAM2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108295073-A | Multi-fluorinated compounds are as bruton's tyrosine kinase inhibitor | 浙江导明医药科技有限公司 | 2018-07-20 | — | — | CN | disclosed |
| CN-106061976-B | Polyfluoro compounds as bruton's tyrosine kinase inhibitors | 浙江导明医药科技有限公司 | 2018-05-15 | — | — | CN | disclosed |
| CN-106061976-A | Polyfluoro compounds as bruton's tyrosine kinase inhibitors | 浙江导明医药科技有限公司 | 2016-10-26 | — | — | CN | disclosed |
| CN-105017256-A | Polyfluorinated compound Bruton tyrosine kinase inhibitor | ZHEJIANG DAOMING PHARMACEUTICAL CO LTD | 2015-11-04 | — | — | CN | disclosed |