SCHEMBL28041360

SCHEMBL28041360

C[Hf](C)C1C=Cc2c(-c3ccc(-c4ccccc4)cc3)cccc21

nearest known ligand 0.32

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
EDNRB P24530 1/20 0.32
EDNRA P25101 1/20 0.32
CHRNB2 P17787 1/20 0.32
CHRNA4 P43681 1/20 0.32
PTGS2 P35354 1/20 0.31
BRD4 O60885 2/20 0.31
PDK2 Q15119 1/20 0.30
PDK4 Q16654 1/20 0.30
PDCD1 Q15116 1/20 0.30
CD274 Q9NZQ7 1/20 0.30
CREBBP Q92793 1/20 0.30
HTR1A P08908 2/20 0.30
HTR7 P34969 2/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27978443 0.97 CHRNB2 (0.33) CHRNB2CHRNA4BRD4PDCD1CD274
SCHEMBL28041134 0.84
SCHEMBL28041264 0.84 BRD4 (0.34) BRD4CREBBP
SCHEMBL28041170 0.84 HRH3 (0.36) CD274
SCHEMBL28041213 0.84 BRD4 (0.34) BRD4CREBBP
SCHEMBL4089009 0.81 CYP2A6 (0.34) CHRNB2CHRNA4PDCD1CD274
SCHEMBL5183967 0.81 CHRNB2 (0.33) CHRNB2CHRNA4BRD4
SCHEMBL17415292 0.80 CHRNB2 (0.31) CHRNB2CHRNA4BRD4
Hydrochloric Acid SCHEMBL5872698 0.79 CHRNB2 (0.33) CHRNB2CHRNA4
SCHEMBL17386746 0.79 HTR7 (0.31) EDNRBEDNRAHTR7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105026408-A Metallocene compound, catalyst for olefin polymer, method for producing olefin polymer, and olefin polymer JAPAN POLYETHYLENE CORP 2015-11-04 CN disclosed