SCHEMBL28041864

SCHEMBL28041864

O=C1CCN(F)c2ccccc21

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 3/20 0.45
LMNA P02545 2/20 0.45
HTT P42858 1/20 0.45
KMT2A Q03164 4/20 0.45
MEN1 O00255 3/20 0.45
CYP2A6 P11509 1/20 0.44
MAOA P21397 1/20 0.44
MAOB P27338 1/20 0.44
NOTUM Q6P988 1/20 0.42
MDM2 Q00987 1/20 0.38
CTDSP1 Q9GZU7 1/20 0.38
ALDH1A1 P00352 5/20 0.37
MAPT P10636 3/20 0.37
CA1 P00915 1/20 0.37
CA2 P00918 1/20 0.37
SRD5A1 P18405 1/20 0.37
KDM4E B2RXH2 1/20 0.37
CYP3A4 P08684 1/20 0.37
PABPC1 P11940 1/20 0.37
BLM P54132 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1253936 0.79 RAB9A (0.47) RAB9ALMNAHTTKMT2AMEN1
SCHEMBL69754 0.76 NOTUM (0.46) RAB9ALMNAHTTKMT2AMEN1
SCHEMBL20418273 0.76 LMNA (0.49) RAB9ALMNAHTTKMT2AMEN1
SCHEMBL10246639 0.76 LMNA (0.45) RAB9ALMNAHTTKMT2AMEN1
SCHEMBL20418099 0.76 LMNA (0.45) RAB9ALMNAHTTKMT2AMEN1
SCHEMBL3388501 0.76 LMNA (0.45) RAB9ALMNAHTTKMT2AMEN1
SCHEMBL31139403 0.76 LMNA (0.42) RAB9ALMNAHTTKMT2AMEN1
SCHEMBL6362813 0.73 KMT2A (0.54) RAB9ALMNAHTTKMT2AMEN1
SCHEMBL13284675 0.72 NR3C1 (0.48) RAB9ALMNAHTTKMT2AMEN1
SCHEMBL14601678 0.72 LMNA (0.42) RAB9ALMNAHTTKMT2AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104981470-A Amino-substituted imidazo[1,2-a]pyridinecarboxamides and their use Bayer Pharma AG 2015-10-14 CN disclosed