Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.55 |
| ▸ | MEN1 | O00255 | 7/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | APAF1 | O14727 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | HTR1A | P08908 | 2/20 | 0.50 |
| ▸ | DRD2 | P14416 | 2/20 | 0.48 |
| ▸ | DRD4 | P21917 | 1/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.47 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | GSK3A | P49840 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL578257 | 0.89 | POLB (0.73) | POLBKMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL30597487 | 0.89 | POLB (0.73) | POLBKMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL24270340 | 0.78 | KMT2A (0.72) | POLBKMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL496680 | 0.76 | POLB (0.61) | POLBKMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL29637973 | 0.76 | POLB (0.61) | POLBKMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL15207803 | 0.76 | CYP11B1 (0.58) | POLBMAPTALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL5807332 | 0.75 | KMT2A (0.59) | POLBKMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL29880432 | 0.75 | POLB (1.00) | POLBKMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL10688767 | 0.75 | POLB (1.00) | POLBKMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL9541791 | 0.74 | MDH2 (0.58) | POLBKMT2AMEN1MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105143463-A | Novel androgen receptor mutation | NOVARTIS AG | 2015-12-09 | — | — | CN | disclosed |