Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDH2 | P40926 | 3/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.57 |
| ▸ | TP53 | P04637 | 2/20 | 0.57 |
| ▸ | TSHR | P16473 | 2/20 | 0.57 |
| ▸ | APAF1 | O14727 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | BCHE | P06276 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.57 |
| ▸ | ACHE | P22303 | 1/20 | 0.57 |
| ▸ | CES1 | P23141 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.55 |
| ▸ | DRD2 | P14416 | 1/20 | 0.54 |
| ▸ | DRD4 | P21917 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 5/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30597487 | 0.83 | POLB (0.73) | MAPTCYP1A2APAF1ALDH1A1HSD17B10 | |
| SCHEMBL578257 | 0.83 | POLB (0.73) | MAPTCYP1A2APAF1ALDH1A1HSD17B10 | |
| SCHEMBL24270340 | 0.81 | KMT2A (0.72) | MAPTTP53TSHRAPAF1ALDH1A1 | |
| SCHEMBL14938439 | 0.77 | MEN1 (0.71) | MDH2MAPTTP53APAF1ALDH1A1 | |
| SCHEMBL1183718 | 0.77 | MDH2 (0.52) | MDH2MAPTCYP1A2TP53TSHR | |
| SCHEMBL6778502 | 0.76 | MAPT (0.49) | MDH2MAPTCYP1A2TP53TSHR | |
| SCHEMBL5766969 | 0.75 | KMT2A (0.73) | MDH2MAPTCYP1A2TP53TSHR | |
| Pyrimidine SCHEMBL28042274 | 0.74 | POLB (0.60) | MAPTCYP1A2APAF1ALDH1A1KMT2A | |
| SCHEMBL28015667 | 0.74 | MEN1 (0.49) | MAPTCYP1A2APAF1ALDH1A1KMT2A | |
| SCHEMBL5394439 | 0.73 | HTR7 (0.53) | MAPTAPAF1ALDH1A1KMT2ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993012786-A1 | INDOLINONE DERIVATIVES | HOWARD HARRY R JR (US) | 1993-07-08 | — | — | WO | disclosed |