Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 9/20 | 0.38 |
| ▸ | TRPC6 | Q9Y210 | 4/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.35 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.35 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.35 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21275520 | 0.76 | TRPC6 (0.37) | TRPC6 | |
| SCHEMBL615145 | 0.74 | ATR (0.47) | EPHX2TRPC6 | |
| SCHEMBL27926722 | 0.73 | TRPC6 (0.51) | EPHX2TRPC6TLR9TLR8TLR7 | |
| SCHEMBL28076399 | 0.72 | EPHX2 (0.39) | EPHX2TRPC6 | |
| SCHEMBL617266 | 0.72 | ATR (0.42) | EPHX2TRPC6 | |
| SCHEMBL15175760 | 0.71 | GPR119 (0.54) | JAK1 | |
| SCHEMBL28042359 | 0.70 | MAPKAPK2 (0.39) | EPHX2TRPC6 | |
| SCHEMBL28042358 | 0.69 | MAP3K12 (0.38) | TRPC6 | |
| SCHEMBL28776119 | 0.68 | MAPT (0.44) | EPHX2 | |
| SCHEMBL26157258 | 0.67 | PIK3CD (0.46) | EPHX2TLR9TLR8TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102264721-B | Compounds useful as inhibitors of ATR kinase | VERTEX PHARMACEUTICALS INC. (US) | 2015-12-09 | — | — | CN | disclosed |