Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 4/20 | 0.45 |
| ▸ | PDE10A | Q9Y233 | 5/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | DHFR | P00374 | 1/20 | 0.40 |
| ▸ | HEXA | P06865 | 1/20 | 0.40 |
| ▸ | HEXB | P07686 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.37 |
| ▸ | USP7 | Q93009 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28042545 | 0.77 | PDE10A (0.68) | PDE10AMAPTDHFRADORA2A | |
| SCHEMBL15904056 | 0.76 | PDE10A (0.57) | EGLN1PDE10AL3MBTL1KDM4EMAPT | |
| SCHEMBL2553742 | 0.69 | ADORA2A (0.58) | L3MBTL1KDM4EMAPTMAPK1NPSR1 | |
| SCHEMBL12629776 | 0.69 | MAPT (0.45) | EGLN1PDE10AL3MBTL1KDM4EMAPT | |
| SCHEMBL1207015 | 0.67 | L3MBTL1 (0.42) | EGLN1L3MBTL1KDM4ESMN1; SMN2 | |
| SCHEMBL515503 | 0.67 | GAA (0.59) | L3MBTL1KDM4EMAPTSMN1; SMN2 | |
| SCHEMBL12235674 | 0.67 | GRM4 (0.49) | L3MBTL1KDM4EMAPTMAPK1NPSR1 | |
| SCHEMBL17736002 | 0.66 | GAA (0.57) | L3MBTL1MAPTSMN1; SMN2 | |
| SCHEMBL513941 | 0.66 | GAA (0.52) | L3MBTL1MAPT | |
| SCHEMBL15904189 | 0.65 | PDE10A (0.72) | PDE10AADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105008346-A | Novel pyrimidine derivatives as phosphodiesterase 10(PDE-10) inhibitors | PALOBIOFARMA SL | 2015-10-28 | — | — | CN | claimed |
| CN-105008346-A | Novel pyrimidine derivatives as phosphodiesterase 10(PDE-10) inhibitors | PALOBIOFARMA SL | 2015-10-28 | — | — | CN | disclosed |