Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | NAAA | Q02083 | 2/20 | 0.44 |
| ▸ | CES2 | O00748 | 4/20 | 0.43 |
| ▸ | CES1 | P23141 | 4/20 | 0.43 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.41 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 3/20 | 0.40 |
| ▸ | PPARD | Q03181 | 3/20 | 0.40 |
| ▸ | PPARA | Q07869 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.40 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.40 |
| ▸ | TLR2 | O60603 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2990381 | 0.92 | NAAA (0.53) | KMT2AMAPTNAAACES2CES1 | |
| SCHEMBL11625205 | 0.92 | NAAA (0.53) | KMT2AMAPTNAAACES2CES1 | |
| SCHEMBL19508699 | 0.92 | NAAA (0.53) | KMT2AMAPTNAAACES2CES1 | |
| SCHEMBL9978409 | 0.92 | KMT2A (0.48) | KMT2AMAPTNAAACES2CES1 | |
| SCHEMBL13485707 | 0.90 | CYP1A2 (0.45) | KMT2AMAPTNAAACES2CES1 | |
| SCHEMBL787945 | 0.88 | CYP1A2 (0.48) | KMT2AMAPTNAAACES2CES1 | |
| Thiophene SCHEMBL27522807 | 0.84 | NAAA (0.40) | KMT2AMAPTNAAACES2CES1 | |
| Thiophene SCHEMBL27504244 | 0.82 | NAAA (0.41) | KMT2AMAPTNAAAL3MBTL1TDP1 | |
| SCHEMBL11928089 | 0.82 | GNAI3 (0.57) | KMT2AMAPTCES2CES1L3MBTL1 | |
| SCHEMBL19500016 | 0.80 | KMT2A (0.43) | KMT2AMAPTNAAACES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105143217-A | Lactam compounds as ep4 receptor-selective agonists for use in the treatment of ep4-mediated diseases and conditions | CAYMAN CHEMICAL CO INC | 2015-12-09 | — | — | CN | disclosed |