Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.31 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.31 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.31 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.31 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3757533 | 0.94 | HPGD (0.36) | HPGDALDH1A1TSHRLMNA | |
| SCHEMBL23388242 | 0.86 | LMNA (0.31) | HPGDALDH1A1TSHRLMNA | |
| SCHEMBL1898846 | 0.86 | LMNA (0.31) | HPGDALDH1A1TSHRLMNA | |
| SCHEMBL1163329 | 0.78 | LMNA (0.32) | HPGDALDH1A1TSHRLMNACHRNB2 | |
| SCHEMBL3762272 | 0.78 | ALDH1A1 (0.40) | HPGDALDH1A1LMNACHRNB2CHRNA3 | |
| SCHEMBL1900474 | 0.78 | — | — | |
| SCHEMBL16041071 | 0.76 | HPGD (0.55) | HPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL28168621 | 0.76 | VNN1 (0.40) | ALDH1A1LMNA | |
| SCHEMBL15614355 | 0.75 | HPGD (0.32) | HPGDALDH1A1 | |
| SCHEMBL7357706 | 0.75 | ALDH1A1 (0.48) | HPGDALDH1A1TSHRHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105324380-A | Pyrrolo[2,3-b]pyridine cdk9 kinase inhibitors | ABBVIE INC | 2016-02-10 | — | — | CN | disclosed |
| CN-105246890-A | Pyrrolo[2, 3-b]pyridine cdk9 kinase inhibitors | ABBVIE INC | 2016-01-13 | — | — | CN | disclosed |