SCHEMBL28043598

SCHEMBL28043598

COC(=O)c1nc(Cl)c(Cl)cc1F

nearest known ligand 0.45

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
NPSR1 Q6W5P4 1/20 0.45
ALDH1A1 P00352 7/20 0.44
ALPL P05186 1/20 0.40
KDM4E B2RXH2 6/20 0.40
PKM P14618 2/20 0.40
RCE1 Q9Y256 1/20 0.40
SMN1; SMN2 Q16637 3/20 0.39
HSD17B10 Q99714 1/20 0.39
MEN1 O00255 1/20 0.39
MAPT P10636 1/20 0.39
CASP3 P42574 1/20 0.39
KMT2A Q03164 1/20 0.39
SENP7 Q9BQF6 1/20 0.39
NQO2 P16083 3/20 0.38
S1PR4 O95977 1/20 0.38
L3MBTL1 Q9Y468 2/20 0.37
RAB9A P51151 1/20 0.37
GAA P10253 1/20 0.37
CGAS Q8N884 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20140437 0.88 NPSR1 (0.47) NPSR1ALDH1A1ALPLKDM4EPKM
SCHEMBL22366827 0.86 NPSR1 (0.45) NPSR1ALDH1A1ALPLKDM4EPKM
SCHEMBL23673380 0.85 NPSR1 (0.44) NPSR1ALDH1A1ALPLKDM4EPKM
SCHEMBL28287874 0.84 NPSR1 (0.50) NPSR1ALDH1A1ALPLKDM4EPKM
SCHEMBL19028097 0.83 NPSR1 (0.42) NPSR1ALDH1A1ALPLKDM4EPKM
SCHEMBL31214243 0.81 CFTR (0.41) NPSR1ALDH1A1KDM4EPKMSMN1; SMN2
SCHEMBL28824010 0.81 NPSR1 (0.47) NPSR1ALDH1A1KDM4EPKMRCE1
SCHEMBL23628471 0.79 NQO2 (0.47) NPSR1ALDH1A1KDM4EPKMRCE1
SCHEMBL7587086 0.78 KEAP1 (0.48) ALDH1A1ALPLSMN1; SMN2HSD17B10MEN1
SCHEMBL31586538 0.78 NPSR1 (0.44) NPSR1ALDH1A1ALPLKDM4EPKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105208859-A Novel 4-aminopyridine and 6-aminopyrimidine carboxylates as herbicides DOW AGROSCIENCES LLC 2015-12-30 CN disclosed
CN-105163588-A 4-amino-6- (4-substituted phenyl) -pyridine-2-carboxylic acid esters and 6-amino-2- (4-substituted phenyl) -pyrimidine-4-carboxylic acid esters and their use as herbicides DOW AGROSCIENCES LLC 2015-12-16 CN disclosed