Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.39 |
| ▸ | MAPT | P10636 | 6/20 | 0.39 |
| ▸ | HPGD | P15428 | 5/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | MYC | P01106 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.36 |
| ▸ | FLT1 | P17948 | 1/20 | 0.36 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27960876 | 0.87 | HPGD (0.39) | ALDH1A1MAPTHPGDGAAMYC | |
| Hydrochloric Acid SCHEMBL28144407 | 0.86 | HPGD (0.38) | ALDH1A1MAPTHPGDGAAMYC | |
| SCHEMBL28044539 | 0.81 | MYC (0.42) | ALDH1A1MAPTHPGDGAAMYC | |
| SCHEMBL44879 | 0.81 | GAA (0.46) | ALDH1A1MAPTHPGDGAAKDM4E | |
| SCHEMBL3809507 | 0.75 | ALDH1A1 (0.53) | SIRT6ALDH1A1MAPTHPGDGAA | |
| SCHEMBL27808166 | 0.73 | NPC1 (0.52) | SIRT6ALDH1A1MAPTHPGDGAA | |
| SCHEMBL5615573 | 0.71 | KDM4E (0.45) | ALDH1A1HPGDKDM4EKMT2AMEN1 | |
| SCHEMBL1098022 | 0.70 | MYC (0.46) | SIRT6ALDH1A1MAPTHPGDMYC | |
| SCHEMBL28338280 | 0.70 | HPGD (0.50) | ALDH1A1MAPTHPGDGAAHTT | |
| SCHEMBL7467830 | 0.70 | MAPT (0.44) | ALDH1A1MAPTHPGDHTTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101594862-B | Substituted indazole derivatives as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2015-11-25 | — | — | CN | disclosed |