Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28044566 | 0.81 | SIRT6 (0.41) | GAAHPGDALDH1A1KMT2AKDM4E | |
| SCHEMBL29040801 | 0.75 | GAA (0.46) | GAATP53HPGDALDH1A1KMT2A | |
| SCHEMBL4675145 | 0.75 | L3MBTL1 (0.38) | GAAHPGDALDH1A1KMT2AL3MBTL1 | |
| SCHEMBL5743752 | 0.74 | ALDH1A1 (0.66) | GAATP53HPGDALDH1A1KMT2A | |
| SCHEMBL27847116 | 0.73 | GAA (0.42) | GAAHPGDALDH1A1KMT2AMEN1 | |
| SCHEMBL28338280 | 0.73 | HPGD (0.50) | GAAHPGDALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL4203044 | 0.73 | ALDH1A1 (0.64) | GAATP53HPGDALDH1A1KMT2A | |
| SCHEMBL28551779 | 0.73 | KMT2A (0.55) | GAATP53HPGDALDH1A1KMT2A | |
| SCHEMBL29181100 | 0.72 | GAA (0.46) | GAATP53HPGDALDH1A1KMT2A | |
| SCHEMBL27960876 | 0.71 | HPGD (0.39) | GAAHPGDALDH1A1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2591354-A1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | Ardelyx, Inc. (US) | 2013-05-15 | — | — | EP | disclosed |
| WO-2012006475-A1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX, INC. (US) | 2012-01-12 | — | — | WO | disclosed |