SCHEMBL28044808

SCHEMBL28044808

CC1CCC(c2ccccc2-c2ccccc2)CC1

nearest known ligand 0.54

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
BRD4 O60885 1/20 0.49
PTGS2 P35354 1/20 0.47
ADRA2A P08913 1/20 0.42
ADRA1D P25100 1/20 0.42
ADRA1A P35348 1/20 0.42
CHRNB2 P17787 1/20 0.40
CHRNA4 P43681 1/20 0.40
PDK2 Q15119 1/20 0.40
PDK4 Q16654 1/20 0.40
CYP11B2 P19099 2/20 0.39
KDM4E B2RXH2 2/20 0.38
ALDH1A1 P00352 2/20 0.38
LMNA P02545 1/20 0.38
MEN1 O00255 1/20 0.38
KMT2A Q03164 1/20 0.38
ATM Q13315 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
ESR2 Q92731 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16393627 0.90 BRD4 (0.51) BRD4PTGS2ADRA2AADRA1DADRA1A
Methyl Alcohol SCHEMBL27626456 0.88 BRD4 (0.51) BRD4PTGS2ADRA2AADRA1DADRA1A
Hydrogen Sulfide SCHEMBL27539552 0.88 BRD4 (0.50) BRD4PTGS2ADRA2AADRA1DADRA1A
Ammonia Solution, Strong SCHEMBL27714733 0.88 BRD4 (0.50) BRD4PTGS2ADRA2AADRA1DADRA1A
Hydrogen Sulfide SCHEMBL27869470 0.82 BRD4 (0.46) BRD4PTGS2ADRA2AADRA1DADRA1A
Boric Acid SCHEMBL29723852 0.82 BRD4 (0.46) BRD4PTGS2ADRA2AADRA1DADRA1A
SCHEMBL10789751 0.82 PTGS2 (0.60) BRD4PTGS2ADRA2AADRA1DADRA1A
SCHEMBL28228917 0.82 PTGS2 (0.56) BRD4PTGS2ADRA2AADRA1DADRA1A
SCHEMBL29433489 0.82 PTGS2 (0.60) BRD4PTGS2ADRA2AADRA1DADRA1A
SCHEMBL10091277 0.81 PDK2 (0.36) BRD4PTGS2CHRNB2CHRNA4PDK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105503961-A A series of PHOLED (phosphorescent organic light-emitting diode) materials SHIJIAZHUANG CHENGZHI YONGHUA DISPLAY MATERIALS CO LTD 2016-04-20 CN disclosed