Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR35 | Q9HC97 | 8/20 | 0.53 |
| ▸ | TTR | P02766 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 5/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6010796 | 0.86 | GPR35 (0.63) | GPR35TTRMAPTLMNAMEN1 | |
| SCHEMBL17295602 | 0.81 | CYP1A2 (0.43) | GPR35TTRMAPTLMNAMEN1 | |
| SCHEMBL310420 | 0.80 | GPR35 (0.69) | GPR35TTRMAPTLMNAMEN1 | |
| Niclofolan SCHEMBL29385615 | 0.80 | GPR35 (0.57) | GPR35TTRMAPTLMNAMEN1 | |
| SCHEMBL4172077 | 0.80 | TTR (0.67) | GPR35TTRMAPTLMNAMEN1 | |
| Niclofolan SCHEMBL1498232 | 0.80 | GPR35 (0.57) | GPR35TTRMAPTLMNAMEN1 | |
| SCHEMBL5654609 | 0.78 | GPR35 (0.66) | GPR35TTRMAPTLMNAMEN1 | |
| SCHEMBL11851949 | 0.78 | MAPT (0.61) | GPR35TTRMAPTLMNAMEN1 | |
| SCHEMBL18304977 | 0.77 | TTR (0.54) | GPR35TTRMAPTLMNAMEN1 | |
| SCHEMBL1248770 | 0.77 | GPR35 (0.65) | GPR35TTRMAPTLMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105209444-A | Benzo-fused heterocyclic derivatives useful as agonists of GPR120 | JANSSEN PHARMACEUTICA NV | 2015-12-30 | — | — | CN | disclosed |