Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACP1 | P24666 | 1/20 | 0.45 |
| ▸ | PDE5A | O76074 | 2/20 | 0.45 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.43 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.43 |
| ▸ | CDK2 | P24941 | 2/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | GBA1 | P04062 | 1/20 | 0.38 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.38 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.38 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2803161 | 0.80 | PDE5A (0.47) | ACP1PDE5ACCNE2CCNE1CDK2 | |
| SCHEMBL13088248 | 0.77 | PDE5A (0.47) | ACP1PDE5AKDM1AADORA2AADORA3 | |
| SCHEMBL3811994 | 0.76 | PDE5A (0.46) | ACP1PDE5ACCNE2CCNE1CDK2 | |
| SCHEMBL2803755 | 0.73 | PDE5A (0.41) | ACP1PDE5AKDM1AADORA2AADORA3 | |
| SCHEMBL30772425 | 0.73 | PDE5A (0.41) | ACP1PDE5AKDM1AADORA2AADORA3 | |
| SCHEMBL2803611 | 0.72 | PDE5A (0.40) | ACP1PDE5ACCNE2CCNE1CDK2 | |
| SCHEMBL2803607 | 0.72 | PDE5A (0.40) | ACP1PDE5ACCNE2CCNE1CDK2 | |
| SCHEMBL14475192 | 0.72 | ABCG2 (0.56) | ACP1PDE5ACCNE2CCNE1CDK2 | |
| SCHEMBL2806792 | 0.70 | PDE5A (0.38) | ACP1PDE5ACCNE2CCNE1CDK2 | |
| SCHEMBL2806796 | 0.70 | PDE5A (0.38) | ACP1PDE5ACCNE2CCNE1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2241565-A1 | Aurora kinase inhibitors compounds | Universität Leipzig (DE) | 2010-10-20 | — | — | EP | disclosed |
| WO-2010081881-A1 | AURORA KINASE INHIBITORS COMPOUNDS. | UNIVERSITÄT LEIPZIG (DE) | 2010-07-22 | — | — | WO | disclosed |