Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.71 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.71 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.71 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | CES2 | O00748 | 1/20 | 0.52 |
| ▸ | CES1 | P23141 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 2-Picolinic Acid SCHEMBL27634356 | 0.87 | LMNA (0.80) | LMNANAPRTP4HTML3MBTL1ALDH1A1 | |
| 2-Picolinic Acid SCHEMBL1698242 | 0.87 | LMNA (0.87) | LMNANAPRTP4HTML3MBTL1ALDH1A1 | |
| 2-Picolinic Acid SCHEMBL27945864 | 0.87 | LMNA (0.87) | LMNANAPRTP4HTML3MBTL1ALDH1A1 | |
| 2-Picolinic Acid SCHEMBL27658889 | 0.87 | LMNA (0.87) | LMNANAPRTP4HTML3MBTL1ALDH1A1 | |
| 2-Picolinic Acid SCHEMBL5694340 | 0.87 | LMNA (0.87) | LMNANAPRTP4HTML3MBTL1ALDH1A1 | |
| 2-Picolinic Acid SCHEMBL27662224 | 0.85 | LMNA (0.83) | LMNANAPRTP4HTML3MBTL1ALDH1A1 | |
| 2-Picolinic Acid SCHEMBL1835270 | 0.85 | LMNA (0.83) | LMNANAPRTP4HTML3MBTL1ALDH1A1 | |
| 2-Picolinic Acid SCHEMBL1995542 | 0.85 | L3MBTL1 (0.91) | LMNANAPRTP4HTML3MBTL1ALDH1A1 | |
| 2-Picolinic Acid SCHEMBL28737810 | 0.84 | LMNA (1.00) | LMNANAPRTP4HTML3MBTL1ALDH1A1 | |
| 2-Picolinic Acid SCHEMBL29368665 | 0.84 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107848976-A | Alkynyl pyridines prolyl hydroxylase inhibitors, its preparation method and medical usage | 江苏恒瑞医药股份有限公司 | 2018-03-27 | — | — | CN | disclosed |
| CN-105130888-A | Pyridylacetylene prolyl hydroxylase inhibitor and preparation method and medical application thereof | UNIV CHINA PHARMA | 2015-12-09 | — | — | CN | disclosed |