Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 2/20 | 0.47 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.32 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.32 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.31 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.31 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6504953 | 0.82 | GABRA1 (0.47) | GABRA1GABRB2ALDH1A1GAAMAPT | |
| SCHEMBL2743774 | 0.80 | GABRA1 (0.62) | GABRA1GABRB2GAAGABRG2GABRB3 | |
| SCHEMBL28332991 | 0.77 | MAPT (0.44) | GABRA1GABRB2ALDH1A1GAAMAPT | |
| SCHEMBL2399172 | 0.75 | GABRA1 (0.52) | GABRA1GABRB2GABRG2GABRB3GABRA2 | |
| SCHEMBL1136214 | 0.74 | GABRA1 (0.47) | GABRA1GABRB2ALDH1A1MAPTL3MBTL1 | |
| SCHEMBL28528612 | 0.74 | GABRA1 (0.56) | GABRA1GABRB2SLC6A2TAAR1MAOA | |
| Carbimide SCHEMBL28662233 | 0.72 | GABRA1 (0.54) | GABRA1GABRB2GABRG2GABRB3SLC6A2 | |
| SCHEMBL28200857 | 0.71 | MAPT (0.49) | GABRA1GABRB2ALDH1A1GAAMAPT | |
| SCHEMBL2042941 | 0.71 | GABRA1 (0.52) | GABRA1GABRB2GABRG2GABRB3GABRA2 | |
| SCHEMBL301137 | 0.71 | GABRA1 (0.52) | GABRA1GABRB2SLC6A2TAAR1MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113896685-B | Indoleamine-2, 3-dioxygenase (IDO) inhibitors | 益方生物科技(上海)股份有限公司 | 2024-02-06 | — | — | CN | disclosed |
| CN-113896685-A | Indoleamine-2, 3-dioxygenase (IDO) inhibitors | 益方生物科技(上海)股份有限公司 | 2022-01-07 | — | — | CN | disclosed |
| CN-105517999-B | IDO inhibitors | 百时美施贵宝公司 | 2019-06-28 | — | — | CN | disclosed |
| CN-105658643-B | IDO inhibitor | 百时美施贵宝公司 | 2019-03-01 | — | — | CN | disclosed |
| CN-109071423-A | Indoleamine-2, 3-dioxygenase (IDO) inhibitors | 益方生物科技（上海）有限公司 | 2018-12-21 | — | — | CN | disclosed |
| CN-105324362-B | Ido inhibitors | 百时美施贵宝公司 | 2017-05-24 | — | — | CN | disclosed |
| CN-105658643-A | Ido inhibitors | 百时美施贵宝公司 | 2016-06-08 | — | — | CN | disclosed |
| CN-105517999-A | Ido inhibitors | BRISTOL MYERS SQUIBB CO | 2016-04-20 | — | — | CN | disclosed |
| CN-105324362-A | Ido inhibitors | BRISTOL MYERS SQUIBB CO | 2016-02-10 | — | — | CN | disclosed |