SCHEMBL28046283

SCHEMBL28046283

CC(=O)NS(=O)(=O)NC(=O)c1ccccc1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC3 O15379 1/20 0.54
CA12 O43570 1/20 0.54
CA1 P00915 1/20 0.54
IDO1 P14902 1/20 0.54
ALOX15 P16050 1/20 0.54
HDAC1 Q13547 1/20 0.54
CA9 Q16790 1/20 0.54
HDAC7 Q8WUI4 1/20 0.54
HDAC2 Q92769 1/20 0.54
HSD17B10 Q99714 1/20 0.54
HDAC8 Q9BY41 1/20 0.54
HDAC6 Q9UBN7 1/20 0.54
NCOR2 Q9Y618 1/20 0.54
LMNA P02545 2/20 0.50
MEN1 O00255 2/20 0.50
KMT2A Q03164 2/20 0.50
L3MBTL1 Q9Y468 2/20 0.50
FLT1 P17948 1/20 0.50
FLT4 P35916 1/20 0.50
KDR P35968 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5819670 0.89 CA12 (0.65) HDAC3CA12CA1IDO1ALOX15
SCHEMBL11289818 0.82 HDAC3 (0.56) HDAC3CA12CA1IDO1ALOX15
SCHEMBL364110 0.79 HDAC3 (0.58) HDAC3CA12CA1IDO1ALOX15
Hydrochloric Acid SCHEMBL4438185 0.78 P4HTM (0.56) HDAC3CA12CA1IDO1ALOX15
SCHEMBL974471 0.78 KMT2A (0.56) HDAC3CA12CA1IDO1ALOX15
SCHEMBL10915393 0.77 HDAC3 (0.50) HDAC3CA12CA1IDO1ALOX15
Benzohydroxamate SCHEMBL20480857 0.77 HDAC6 (0.82) HDAC3CA12CA1IDO1ALOX15
SCHEMBL3729389 0.77 CA12 (0.60) HDAC3CA12CA1IDO1ALOX15
Dimethylamine SCHEMBL15266781 0.76 HDAC3 (0.54) HDAC3CA12CA1IDO1ALOX15
SCHEMBL1370670 0.76 LMNA (0.54) HDAC3CA12CA1IDO1ALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-102264226-B Bicyclooctane-1, the 3-derovatives of phenyl-replacement BAYER INTELLECTUAL PROPERTY GMBH (DE) 2015-12-16 CN disclosed