SCHEMBL364110

SCHEMBL364110

CS(=O)(=O)NC(=O)c1ccccc1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC3 O15379 1/20 0.58
CA12 O43570 1/20 0.58
CA1 P00915 1/20 0.58
IDO1 P14902 1/20 0.58
ALOX15 P16050 1/20 0.58
HDAC1 Q13547 1/20 0.58
CA9 Q16790 1/20 0.58
HDAC7 Q8WUI4 1/20 0.58
HDAC2 Q92769 1/20 0.58
HSD17B10 Q99714 1/20 0.58
HDAC8 Q9BY41 1/20 0.58
HDAC6 Q9UBN7 1/20 0.58
NCOR2 Q9Y618 1/20 0.58
P4HTM Q9NXG6 2/20 0.54
GAA P10253 1/20 0.54
KMT2A Q03164 3/20 0.53
LMNA P02545 2/20 0.53
MEN1 O00255 2/20 0.53
FLT1 P17948 1/20 0.53
FLT4 P35916 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL4438185 0.98 P4HTM (0.56) HDAC3CA12CA1IDO1ALOX15
Dimethylamine SCHEMBL15266781 0.96 HDAC3 (0.54) HDAC3CA12CA1IDO1ALOX15
Methylene Chloride SCHEMBL27549628 0.92 GAA (0.52) HDAC3CA12CA1IDO1ALOX15
SCHEMBL31331542 0.88 SCN9A (0.64) P4HTMKMT2AMEN1SCN9ASCN3A
SCHEMBL13296132 0.84 RAB9A (0.55) HDAC3CA12CA1IDO1ALOX15
SCHEMBL5819670 0.84 CA12 (0.65) HDAC3CA12CA1IDO1ALOX15
SCHEMBL2159159 0.83 PKM (0.51) CA12CA1HDAC1CA9HDAC2
SCHEMBL1021023 0.81 ALDH1A1 (0.44) HDAC3CA12CA1IDO1ALOX15
Styrene SCHEMBL8438571 0.81 HDAC1 (0.51) CA1HDAC1CA9HDAC2P4HTM
SCHEMBL11289818 0.81 HDAC3 (0.56) HDAC3CA12CA1IDO1ALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 224 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240335442-A1 N-ACYLHYDRAZONE COMPOUNDS CAPABLE OF INHIBITING NAV1.7 AND/OR NAV1.8, PROCESSES FOR THE PREPARATION THEREOF, COMPOSITIONS, USES, METHODS FOR TREATMENT USING SAME, AND KITS UNIVERSIDADE FEDERAL DO RIO DE JANEIRO – UFRJ (BR) 2024-10-10 US claimed
EP-4382100-A1 N-ACYLHYDRAZONE COMPOUNDS CAPABLE OF INHIBITING NAV1.7 AND/OR NAV1.8, PROCESSES FOR THE PREPARATION THEREOF, COMPOSITIONS, USES, METHODS FOR TREATMENT USING SAME, AND KITS Eurofarma Laboratórios S.A. (BR) 2024-06-12 EP claimed
CN-118076348-A N-acylhydrazone compounds capable of inhibiting NAV 1.7 and/or NAV 1.8, methods of making, compositions, uses, methods of treatment and kits using the same 欧罗法玛实验室股份公司 2024-05-24 CN claimed
CN-111295382-B Bridged bicyclic compounds as farnesyl ester X receptor modulators 百时美施贵宝公司 2024-02-02 CN claimed
WO-2023122938-A1 HETEROCYCLIC COMPOUNDS AS SHP2 INHIBITORS, COMPOSITIONS COMPRISING THE HETEROCYCLIC COMPOUND, AND METHODS OF USE THEREOF JS INNOMED HOLDINGS LTD. (KY) 2023-07-06 WO claimed
EP-3749646-A1 HETEROARYL COMPOUNDS AS KINASE INHIBITOR Fujian Haixi Pharmaceuticals Co., Ltd (CN) 2020-12-16 EP claimed
EP-3697791-A1 HETEROCYCLIC COMPOUNDS, COMPOSITIONS COMPRISING HETEROCYCLIC COMPOUND, AND METHODS OF USE THEREOF JS Innopharm (Shanghai) Ltd. (CN) 2020-08-26 EP claimed
WO-2019174601-A1 HETEROARYL COMPOUNDS AS KINASE INHIBITOR FUJIAN HAIXI PHARMACEUTICALS CO., LTD (CN) 2019-09-19 WO claimed
WO-2019076358-A1 HETEROCYCLIC COMPOUNDS, COMPOSITIONS COMPRISING HETEROCYCLIC COMPOUND, AND METHODS OF USE THEREOF JS INNOPHARM (SHANGHAI) LTD (CN) 2019-04-25 WO claimed
EP-3256449-A2 SODIUM CHANNEL BLOCKERS Daewoong Pharmaceutical Co., Ltd. (KR) 2017-12-20 EP claimed
EP-1221848-A1 SELECTIVE HERBICIDES ON THE BASIS OF N-ARYL-TRIAZOLINE(THI)ONES Bayer Aktiengesellschaft (DE) 2002-07-17 EP claimed
US-6297192-B1 MIXTURES OF HERBICIDES BAYER AKTIENGESELLSCHAFT (DE) 2001-10-02 US claimed
CN-1071743-C Sulfuryl or sulfinyl benzoyl guanidine derivative MERCK PATENT GMBH (DE) 2001-09-26 CN claimed
CN-1310700-A Preparation method of ortho-alkylated benzoic acid derivative MERCK PATENT GMBH (DE) 2001-08-29 CN claimed
WO-2001039597-A2 N-ARYL-URACILE-BASED HERBICIDES BAYER AKTIENGESELLSCHAFT (DE) 2001-06-07 WO claimed
WO-2001022819-A1 SELECTIVE HERBICIDES ON THE BASIS OF N-ARYL-TRIAZOLINE(THI)ONES BAYER AKTIENGESELLSCHAFT (DE) 2001-04-05 WO claimed
EP-1049376-A1 SELECTIVE HERBICIDES BASED ON N-ARYL- TRIAZOLINE(THI)ONS AND N-ARLYSULFONYLAMINO (THIO)CARBONYL- TRIAZOLINE(THI) ONS Bayer Aktiengesellschaft (DE) 2000-11-08 EP claimed
WO-1999037153-A1 SELECTIVE HERBICIDES BASED ON N-ARYL- TRIAZOLINE(THI)ONS AND N-ARLYSULFONYLAMINO (THIO)CARBONYL- TRIAZOLINE(THI) ONS BAYER AKTIENGESELLSCHAFT (DE) 1999-07-29 WO claimed
US-5744641-A Sulfonyl- or sulfinylbenzoylguanidine derivatives MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 1998-04-28 US claimed
CN-1148590-A Sulfuryl or sulfinyl benzoyl guanidine derivative MERCK PATENT GMBH (DE) 1997-04-30 CN claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240335442-A1 N-ACYLHYDRAZONE COMPOUNDS CAPABLE OF INHIBITING NAV1.7 AND/OR NAV1.8, PROCESSES FOR THE PREPARATION THEREOF, COMPOSITIONS, USES, METHODS FOR TREATMENT USING SAME, AND KITS SCN1A, SCN7A, SCN8A HDAC3 140/4885CA12 2541/4885CA1 699/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.