Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.37 |
| ▸ | NOS3 | P29474 | 5/20 | 0.36 |
| ▸ | NOS2 | P35228 | 5/20 | 0.36 |
| ▸ | NOS1 | P29475 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PARG | Q86W56 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | F12 | P00748 | 1/20 | 0.34 |
| ▸ | PLAU | P00749 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14627578 | 0.80 | NOS3 (0.50) | PDPK1MAPTFGFR1SRCNOS3 | |
| SCHEMBL25368878 | 0.78 | MAPT (0.47) | MAPTLMNACYP3A4APEX1MAPK1 | |
| SCHEMBL3068849 | 0.74 | CYP3A4 (0.43) | MAPTLMNACYP3A4APEX1MAPK1 | |
| SCHEMBL558996 | 0.73 | PDPK1 (0.53) | PDPK1FGFR1SRCMEN1KMT2A | |
| SCHEMBL4000886 | 0.73 | CASP6 (0.49) | MAPTLMNACYP3A4APEX1MAPK1 | |
| SCHEMBL558479 | 0.73 | PDPK1 (0.44) | PDPK1CYP3A4FGFR1SRCPIK3CD | |
| SCHEMBL31686325 | 0.73 | PDPK1 (0.40) | PDPK1MAPTLMNANOS3NOS2 | |
| SCHEMBL15124778 | 0.73 | LMNA (0.44) | MAPTLMNACYP3A4APEX1MAPK1 | |
| SCHEMBL30576347 | 0.73 | LMNA (0.44) | MAPTLMNACYP3A4APEX1MAPK1 | |
| SCHEMBL22589259 | 0.71 | LMNA (0.42) | MAPTLMNACYP3A4APEX1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103261167-B | 6 of replacement, 6-condenses nitrogen-containing heterocycle compound and uses thereof | HOFFMAN-LA ROCHE LTD. (CH) | 2016-05-04 | — | — | CN | disclosed |