Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.43 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.42 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CDC7 | O00311 | 1/20 | 0.40 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.40 |
| ▸ | USP10 | Q14694 | 1/20 | 0.40 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.40 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.40 |
| ▸ | BRAF | P15056 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28047041 | 0.84 | MAPT (0.52) | MAPTNPSR1LMNAKDM4EMEN1 | |
| SCHEMBL28047081 | 0.82 | MAPT (0.47) | MAPTNPSR1LMNAKDM4EMEN1 | |
| SCHEMBL9795426 | 0.78 | USP10 (0.44) | MAPTLMNAKDM4EMEN1KMT2A | |
| SCHEMBL15933999 | 0.73 | GPBAR1 (0.54) | — | |
| SCHEMBL267821 | 0.72 | MAPT (0.65) | MAPTTDP1NPSR1LMNAMEN1 | |
| SCHEMBL9371773 | 0.71 | MAPT (0.47) | MAPTTDP1NPSR1LMNAKDM4E | |
| SCHEMBL3455065 | 0.70 | TRPM8 (0.52) | MAPTLMNAKDM4EMEN1KMT2A | |
| SCHEMBL17977274 | 0.70 | MAPT (0.48) | MAPTNPSR1LMNAKDM4EMEN1 | |
| SCHEMBL28047023 | 0.69 | RHEB (0.42) | MAPTKDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL316689 | 0.69 | MAPT (0.57) | MAPTTDP1NPSR1LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105164112-A | Amide compound and preparation method, pharmaceutical composition and application thereof | SHANGHAI INST MATERIA MEDICA | 2015-12-16 | — | — | CN | disclosed |