Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.42 |
| ▸ | PPM1D | O15297 | 2/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | ACE2 | Q9BYF1 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CA4 | P22748 | 1/20 | 0.37 |
| ▸ | CA6 | P23280 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28105519 | 0.93 | PPM1D (0.45) | KDM4EGRIK1PPM1DPTPN1TSHR | |
| SCHEMBL28048040 | 0.93 | PPM1D (0.48) | KDM4EPPM1DPTPN1ALDH1A1KMT2A | |
| SCHEMBL28835261 | 0.92 | GRIK1 (0.38) | KDM4EGRIK1PPM1DPTPN1TSHR | |
| SCHEMBL27741282 | 0.92 | PPM1D (0.50) | KDM4EPPM1DKMT2AGAA | |
| SCHEMBL27762499 | 0.89 | KDM1A (0.43) | KDM4EGRIK1PPM1DPTPN1MEN1 | |
| SCHEMBL28056149 | 0.83 | PPM1D (0.41) | KDM4EPPM1DPTPN1TSHRALDH1A1 | |
| SCHEMBL27552080 | 0.83 | KDM4E (0.44) | KDM4EGRIK1PPM1DPTPN1TSHR | |
| SCHEMBL29446092 | 0.81 | PPM1D (0.49) | KDM4EPPM1DPTPN1ACE2KMT2A | |
| SCHEMBL3647579 | 0.80 | GRIK1 (0.58) | KDM4EGRIK1PPM1DTSHRALDH1A1 | |
| SCHEMBL547637 | 0.80 | GRIK1 (0.58) | KDM4EGRIK1PPM1DTSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105164134-A | Imidazo-triazine derivatives as pde10 inhibitors | PFIZER | 2015-12-16 | — | — | CN | claimed |
| CN-107074861-A | 9H pyrimido [4,5-B ] indoles and related analogs as BET bromodomain inhibitors | 密执安大学评议会 | 2017-08-18 | — | — | CN | disclosed |
| CN-106661043-A | 2-oxa-5-azabicyclo[2.2.1]heptan-3-yl derivatives | 豪夫迈·罗氏有限公司 | 2017-05-10 | — | — | CN | disclosed |
| CN-105164134-A | Imidazo-triazine derivatives as pde10 inhibitors | PFIZER | 2015-12-16 | — | — | CN | disclosed |