Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 2/20 | 0.38 |
| ▸ | PPM1D | O15297 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | PLA2G2D | Q9UNK4 | 1/20 | 0.35 |
| ▸ | LIPC | P11150 | 1/20 | 0.35 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.35 |
| ▸ | RXRA | P19793 | 1/20 | 0.34 |
| ▸ | ACE2 | Q9BYF1 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28047118 | 0.92 | KDM4E (0.42) | GRIK1PPM1DKDM4EPTPN1TSHR | |
| SCHEMBL28048040 | 0.86 | PPM1D (0.48) | PPM1DKDM4EPTPN1ALDH1A1KMT2A | |
| SCHEMBL28105519 | 0.86 | PPM1D (0.45) | GRIK1PPM1DKDM4EPTPN1TSHR | |
| SCHEMBL27741282 | 0.85 | PPM1D (0.50) | PPM1DKDM4EKMT2A | |
| SCHEMBL27762499 | 0.82 | KDM1A (0.43) | GRIK1PPM1DKDM4EPTPN1MEN1 | |
| SCHEMBL28106042 | 0.79 | KDM4E (0.37) | KDM4EPTPN1TSHRALDH1A1MAPK1 | |
| SCHEMBL28056149 | 0.77 | PPM1D (0.41) | PPM1DKDM4EPTPN1TSHRALDH1A1 | |
| SCHEMBL27552080 | 0.77 | KDM4E (0.44) | GRIK1PPM1DKDM4EPTPN1TSHR | |
| SCHEMBL29446092 | 0.75 | PPM1D (0.49) | PPM1DKDM4EPTPN1ACE2KMT2A | |
| SCHEMBL547637 | 0.74 | GRIK1 (0.58) | GRIK1PPM1DKDM4ETSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106188038-A | One class has the compound of kinase inhibiting activity, preparation method and purposes | 中国科学院上海药物研究所 | 2016-12-07 | — | — | CN | disclosed |