Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPM1D | O15297 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | LIPG | Q9Y5X9 | 2/20 | 0.37 |
| ▸ | LIPC | P11150 | 1/20 | 0.37 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28056103 | 0.94 | PPM1D (0.44) | PPM1DKDM4ETSHRALDH1A1FOLH1 | |
| SCHEMBL28056027 | 0.94 | PPM1D (0.47) | PPM1DKDM4ETBK1GAACEL | |
| SCHEMBL28047118 | 0.83 | KDM4E (0.42) | PPM1DKDM4ETSHRALDH1A1MAPK1 | |
| SCHEMBL2361733 | 0.81 | PPM1D (0.52) | PPM1DKDM4ETBK1GAACEL | |
| SCHEMBL27792967 | 0.78 | KDM4E (0.46) | KDM4ETSHRALDH1A1MAPK1FOLH1 | |
| SCHEMBL28048040 | 0.77 | PPM1D (0.48) | PPM1DKDM4EALDH1A1PTPN1GAA | |
| SCHEMBL28105519 | 0.77 | PPM1D (0.45) | PPM1DKDM4ETSHRALDH1A1MAPK1 | |
| SCHEMBL28835261 | 0.77 | GRIK1 (0.38) | PPM1DKDM4ETSHRALDH1A1MAPK1 | |
| SCHEMBL27741282 | 0.76 | PPM1D (0.50) | PPM1DKDM4EGAACELKMT2A | |
| SCHEMBL1355580 | 0.76 | RXRA (0.48) | KDM4ETSHRALDH1A1FOLH1PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105407888-A | Novel bicyclic bromodomain inhibitors | ZENITH EPIGENETICS CORP | 2016-03-16 | — | — | CN | claimed |
| CN-107106561-A | Heparan sulfate biosynthesis inhibitor for treating disease | 生物马林药物股份有限公司 | 2017-08-29 | — | — | CN | disclosed |
| CN-105407888-A | Novel bicyclic bromodomain inhibitors | ZENITH EPIGENETICS CORP | 2016-03-16 | — | — | CN | disclosed |