Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPM1D | O15297 | 2/20 | 0.48 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.43 |
| ▸ | KDM5A | P29375 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | KMO | O15229 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | CEL | P19835 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.39 |
| ▸ | RARB | P10826 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27741282 | 0.98 | PPM1D (0.50) | PPM1DKDM5BKDM5AKMT2AKMO | |
| SCHEMBL28105519 | 0.97 | PPM1D (0.45) | PPM1DKDM5BKDM5AKMT2AKMO | |
| SCHEMBL28047118 | 0.93 | KDM4E (0.42) | PPM1DKMT2AGAAKDM4EPTPN1 | |
| SCHEMBL29446092 | 0.89 | PPM1D (0.49) | PPM1DKDM5BKDM5AKMT2AKMO | |
| SCHEMBL3853181 | 0.87 | PPM1D (0.51) | PPM1DKDM5BKDM5AKMT2AKMO | |
| SCHEMBL27762499 | 0.86 | KDM1A (0.43) | PPM1DKMT2AKDM4EPTPN1 | |
| SCHEMBL28835261 | 0.86 | GRIK1 (0.38) | PPM1DKMT2AKDM4EPTPN1ALDH1A1 | |
| SCHEMBL28056027 | 0.84 | PPM1D (0.47) | PPM1DKMT2AKMOHSD17B10GAA | |
| SCHEMBL28056103 | 0.81 | PPM1D (0.44) | PPM1DKMT2AHSD17B10GAAKDM4E | |
| SCHEMBL27682569 | 0.81 | HCAR3 (0.36) | PPM1DKMT2AKMOHSD17B10GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105130986-A | Pyrimidine or pyridino-pyridone compound and application thereof | GUANGZHOU KEQIN NEW MEDICINE DEV CO LTD | 2015-12-09 | — | — | CN | disclosed |