Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Adipic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.55 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 4/20 | 0.65 |
| ▸ | BLM | P54132 | 2/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.62 |
| ▸ | TSHR | P16473 | 5/20 | 0.61 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.61 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | THRB | P10828 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.55 |
| ▸ | PLG | P00747 | 1/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.55 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.52 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.52 |
| ▸ | GABRP | O00591 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Adipic Acid SCHEMBL1071331 | 0.97 | LMNA (0.69) | LMNABLMNPSR1TSHRNFKB1 | |
| Glutarate SCHEMBL4148651 | 0.91 | SLC22A6 (0.69) | LMNABLMNPSR1TSHRNFKB1 | |
| Gamma-Aminobutyric Acid SCHEMBL28266648 | 0.87 | LMNA (0.75) | LMNABLMNPSR1TSHRNFKB1 | |
| SCHEMBL31321733 | 0.86 | LMNA (0.61) | LMNABLMNPSR1TSHRNFKB1 | |
| Hydrochloric Acid SCHEMBL3143617 | 0.85 | LMNA (0.69) | LMNABLMNPSR1TSHRNFKB1 | |
| Hydrochloric Acid SCHEMBL1329236 | 0.85 | LMNA (0.69) | LMNABLMNPSR1TSHRNFKB1 | |
| Hexanoate SCHEMBL2020032 | 0.85 | AKR1B1 (0.76) | LMNABLMNPSR1TSHRSLC22A6 | |
| Succinic Acid SCHEMBL1071158 | 0.84 | LMNA (0.64) | LMNABLMNPSR1TSHRNFKB1 | |
| Adipic Acid SCHEMBL515200 | 0.84 | LMNA (0.92) | LMNABLMNPSR1TSHRNFKB1 | |
| Adipic Acid SCHEMBL1963560 | 0.84 | LMNA (0.92) | LMNABLMNPSR1TSHRNFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105315459-B | A kind of preparation method of polyadipate base guanidine hydrochloride | 吉林云飞医药有限公司 | 2017-09-26 | — | — | CN | disclosed |
| CN-105315459-B | A kind of preparation method of polyadipate base guanidine hydrochloride | 吉林云飞医药有限公司 | 2017-09-26 | — | — | CN | disclosed |
| CN-105315459-A | Preparation method for poly(guanidine hydrochloride adipate | JILIN YUNFEI PHARMACEUTICAL CO LTD | 2016-02-10 | — | — | CN | disclosed |