Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.55 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.55 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.47 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.47 |
| ▸ | CDK8 | P49336 | 2/20 | 0.47 |
| ▸ | PRKX | P51817 | 2/20 | 0.47 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.47 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.47 |
| ▸ | PRKACA | P17612 | 1/20 | 0.47 |
| ▸ | LTK | P29376 | 1/20 | 0.47 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.47 |
| ▸ | CLK2 | P49760 | 1/20 | 0.47 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.47 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.47 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.47 |
| ▸ | PIM1 | P11309 | 2/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7072379 | 0.84 | FGFR1 (0.57) | MKNK1MKNK2AURKBPRKACACLK2 | |
| SCHEMBL28253335 | 0.79 | FGFR1 (0.57) | CLK2CLK4PIM1FGFR1METAP2 | |
| SCHEMBL29468203 | 0.76 | NOS1 (0.59) | AURKBMAP4K4PDGFRBPDGFRACDK8 | |
| SCHEMBL1274135 | 0.76 | NOS1 (0.59) | AURKBMAP4K4PDGFRBPDGFRACDK8 | |
| SCHEMBL23901368 | 0.75 | NTRK1 (0.52) | NTRK1ROCK2GSK3BROCK1METAP2 | |
| SCHEMBL28037237 | 0.75 | AHR (0.58) | — | |
| SCHEMBL8669605 | 0.75 | NOS1 (0.57) | FGFR1METAP2INSRIGF1RNOS1 | |
| SCHEMBL3300303 | 0.74 | TAAR1 (0.60) | HCAR2 | |
| SCHEMBL879376 | 0.72 | NOS1 (0.53) | FGFR1METAP2INSRIGF1RNOS1 | |
| SCHEMBL30896276 | 0.72 | NOS1 (0.58) | FGFR1METAP2INSRIGF1RNOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105189481-A | Pyridine cdk9 kinase inhibitors | ABBVIE INC | 2015-12-23 | — | — | CN | disclosed |