Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.42 |
| ▸ | TTR | P02766 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | THRB | P10828 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | RECQL | P46063 | 3/20 | 0.34 |
| ▸ | BLM | P54132 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30349926 | 0.90 | AURKA (0.44) | AURKAAURKBTTRCYP1A2CTRB1 | |
| SCHEMBL433199 | 0.90 | AURKA (0.44) | AURKAAURKBTTRCYP1A2CTRB1 | |
| SCHEMBL6135405 | 0.89 | AURKA (0.40) | AURKAAURKBTTRCYP1A2CTRB1 | |
| SCHEMBL6687050 | 0.82 | CTRB1 (0.43) | AURKAAURKBTTRCYP1A2CTRB1 | |
| SCHEMBL10001904 | 0.81 | AURKA (0.47) | AURKAAURKBTTRCYP1A2CTRB1 | |
| SCHEMBL18315988 | 0.81 | CTRB1 (0.42) | AURKAAURKBTTRCYP1A2CTRB1 | |
| SCHEMBL18315990 | 0.81 | CTRB1 (0.42) | AURKAAURKBCYP1A2CTRB1ALDH1A1 | |
| SCHEMBL11528264 | 0.79 | AURKA (0.46) | AURKAAURKBTTRCYP1A2CTRB1 | |
| SCHEMBL6535450 | 0.79 | AURKA (0.38) | AURKAAURKBTTRCYP1A2CTRB1 | |
| SCHEMBL17121328 | 0.78 | AURKA (0.56) | AURKAAURKBTTRCYP1A2CTRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105121471-A | Pertuzumab variants and evaluation thereof | HOFFMANN LA ROCHE | 2015-12-02 | — | — | CN | disclosed |