Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | AOC3 | Q16853 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ASAH1 | Q13510 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27552003 | 0.85 | SIGMAR1 (0.55) | LMNA | |
| SCHEMBL5610050 | 0.84 | RIPK1 (0.52) | RIPK1LMNAKDM4EL3MBTL1AOC3 | |
| SCHEMBL8710104 | 0.82 | RIPK1 (0.61) | RIPK1LMNAKDM4EL3MBTL1AOC3 | |
| SCHEMBL4837244 | 0.82 | RIPK1 (0.61) | RIPK1LMNAKDM4EL3MBTL1AOC3 | |
| SCHEMBL11828179 | 0.82 | RIPK1 (0.61) | RIPK1LMNAKDM4EL3MBTL1AOC3 | |
| SCHEMBL29860819 | 0.82 | RIPK1 (0.61) | RIPK1LMNAKDM4EL3MBTL1AOC3 | |
| SCHEMBL5185803 | 0.79 | RIPK1 (0.64) | RIPK1LMNAKDM4EL3MBTL1AOC3 | |
| SCHEMBL3081755 | 0.79 | RIPK1 (0.64) | RIPK1LMNAKDM4EL3MBTL1AOC3 | |
| SCHEMBL7766257 | 0.79 | SIGMAR1 (0.58) | LMNA | |
| SCHEMBL8742857 | 0.79 | HDAC3 (0.50) | RIPK1LMNAKDM4EL3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105209428-A | Substituted 3-phenylpropylamine derivatives for the treatment of ophthalmic diseases and disorders | ACUCELA INC | 2015-12-30 | — | — | CN | disclosed |