Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.49 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.49 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | ACHE | P22303 | 1/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.49 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.46 |
| ▸ | PYCR1 | P32322 | 3/20 | 0.40 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.39 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.39 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | ESRRG | P62508 | 1/20 | 0.38 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10223590 | 0.80 | KCNH2 (0.64) | LMNAKCNH2SIGMAR1NR1I2ADRA2A | |
| SCHEMBL18714772 | 0.79 | SIGMAR1 (0.50) | LMNAKCNH2SIGMAR1NR1I2ADRA2A | |
| SCHEMBL10272590 | 0.79 | LMNA (0.47) | LMNAKCNH2SIGMAR1NR1I2ADRA2A | |
| SCHEMBL12449593 | 0.79 | SIGMAR1 (0.47) | LMNAKCNH2SIGMAR1NR1I2ADRA2A | |
| SCHEMBL18714779 | 0.79 | SIGMAR1 (0.50) | LMNAKCNH2SIGMAR1NR1I2ADRA2A | |
| SCHEMBL12891088 | 0.79 | KCNH2 (0.53) | LMNAKCNH2SIGMAR1NR1I2ADRA2A | |
| SCHEMBL12201774 | 0.77 | SIGMAR1 (0.56) | LMNAKCNH2SIGMAR1NR1I2ADRA2A | |
| SCHEMBL25530530 | 0.77 | LMNA (0.51) | LMNAKCNH2SIGMAR1NR1I2ADRA2A | |
| SCHEMBL3377392 | 0.76 | CARM1 (0.64) | LMNASIGMAR1PYCR1CARM1PRMT6 | |
| SCHEMBL18714849 | 0.76 | SIGMAR1 (0.58) | LMNAKCNH2SIGMAR1NR1I2ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105218399-A | A kind of substituted acethydrazide derivatives, Preparation Method And The Use | INST PHARM & TOXICOLOGY AMMS | 2016-01-06 | — | — | CN | disclosed |