SCHEMBL28049501

SCHEMBL28049501

O=[N+]([O-])c1ccc(OCOCOc2ccc([N+](=O)[O-])cc2)cc1

nearest known ligand 0.56

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.56
PTGS2 P35354 1/20 0.56
HSPB1 P04792 1/20 0.52
CA1 P00915 3/20 0.51
CA2 P00918 3/20 0.51
CA9 Q16790 2/20 0.51
CA12 O43570 1/20 0.51
CA7 P43166 1/20 0.51
DRD2 P14416 1/20 0.51
DRD4 P21917 1/20 0.51
DRD3 P35462 1/20 0.51
KCNH2 Q12809 1/20 0.51
MAPT P10636 3/20 0.50
MAOB P27338 2/20 0.50
ALDH1A1 P00352 2/20 0.50
AOC3 Q16853 1/20 0.50
POLB P06746 1/20 0.50
CES2 O00748 1/20 0.50
CES1 P23141 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8746688 0.93 LMNA (0.58) LMNAPTGS2HSPB1CA1CA2
Hydrochloric Acid SCHEMBL10553766 0.91 LMNA (0.56) LMNAPTGS2HSPB1CA1CA2
Hydrochloric Acid SCHEMBL10553753 0.91 LMNA (0.56) LMNAPTGS2HSPB1CA1CA2
SCHEMBL25383095 0.88 LMNA (0.50) LMNAPTGS2HSPB1CA1CA2
SCHEMBL27445875 0.88 PTGS2 (0.63) LMNAPTGS2CA1CA2KCNH2
SCHEMBL3132216 0.86 PTGS2 (0.56) LMNAPTGS2CA1CA2CA9
SCHEMBL6228523 0.84 MAPT (0.65) LMNAPTGS2DRD2DRD4DRD3
SCHEMBL8417803 0.84 LMNA (0.52) LMNAPTGS2CA1CA2DRD2
SCHEMBL6818587 0.84 KCNH2 (0.49) LMNAPTGS2CA1CA2CA9
SCHEMBL8456712 0.83 ALDH1A1 (0.62) LMNAPTGS2DRD2DRD4DRD3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105384668-B The method for being used to prepare ether compound 住友化学株式会社 2018-10-09 CN disclosed
CN-105384668-A Method for preparing ether compound SUMITOMO CHEMICAL CO 2016-03-09 CN disclosed