Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 8/20 | 0.60 |
| ▸ | CHRNA4 | P43681 | 8/20 | 0.60 |
| ▸ | CHRNA3 | P32297 | 6/20 | 0.60 |
| ▸ | CHRNB4 | P30926 | 5/20 | 0.60 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.60 |
| ▸ | CHRNA1 | P02708 | 2/20 | 0.60 |
| ▸ | CHRNB1 | P11230 | 2/20 | 0.60 |
| ▸ | CHRNG | P07510 | 1/20 | 0.60 |
| ▸ | CHRND | Q07001 | 1/20 | 0.60 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31680951 | 0.91 | CHRNB2 (0.66) | CHRNB2CHRNA4CHRNA3CHRNB4CHRNA7 | |
| SCHEMBL10280025 | 0.91 | CHRNB2 (0.66) | CHRNB2CHRNA4CHRNA3CHRNB4CHRNA7 | |
| SCHEMBL2240323 | 0.84 | CHRNB2 (0.66) | CHRNB2CHRNA4CHRNA3CHRNB4CHRNA7 | |
| Dimethylamine SCHEMBL27735845 | 0.84 | CHRNB2 (0.57) | CHRNB2CHRNA4CHRNA3CHRNB4CHRNA7 | |
| SCHEMBL586350 | 0.82 | CHRNB2 (0.60) | CHRNB2CHRNA4CHRNA3CHRNB4CHRNA7 | |
| SCHEMBL20038029 | 0.80 | CHRNB2 (0.60) | CHRNB2CHRNA4CHRNA3CHRNB4CHRNA7 | |
| SCHEMBL8356592 | 0.78 | PARP15 (0.57) | — | |
| SCHEMBL10559372 | 0.78 | PARP15 (0.45) | CHRNB2CHRNA4CHRNA3CHRNB4CHRNA7 | |
| SCHEMBL24183611 | 0.78 | CHRNB2 (0.54) | CHRNB2CHRNA4CHRNA3CHRNB4CHRNA7 | |
| SCHEMBL24154367 | 0.77 | CHRNA3 (0.78) | CHRNB2CHRNA4CHRNA3CHRNB4CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104781258-B | Hydroxy-substituted imidazo [1,2-a ] pyridinecarboxamides and their use as soluble guanylate cyclase stimulators | 拜耳制药股份公司 | 2017-09-22 | — | — | CN | disclosed |
| CN-105339368-B | Imidazo [1,2 a] pyridine of 3 aryl substitution and application thereof | 拜耳制药股份公司 | 2017-08-15 | — | — | CN | disclosed |
| CN-107001361-A | Heteroaryl substituted imidazo [1, 2-a ] pyridines and their use | 拜耳医药股份有限公司 | 2017-08-01 | — | — | CN | disclosed |
| CN-106715426-A | Cyano-substituted imidazo[1,2-a]pyridinecarboxamides and their use | 拜耳医药股份有限公司 | 2017-05-24 | — | — | CN | disclosed |
| CN-104981470-B | Amino-substituted imidazo[1,2-a]pyridinecarboxamides and their use | 拜耳制药股份公司 | 2017-04-19 | — | — | CN | disclosed |
| CN-104955823-B | Carboxy-substituted imidazo [1,2-a ] pyridinecarboxamides and their use as stimulators of soluble guanylate cyclase | 拜耳制药股份公司 | 2017-04-19 | — | — | CN | disclosed |
| CN-106414440-A | Aryl and heteroaryl substituted imidazo [1,2-a ] pyridine-3-carboxamides and their use | 拜耳制药股份公司 | 2017-02-15 | — | — | CN | disclosed |
| CN-105263490-A | Substituted triazolopyridines and methods of use | GENENTECH INC | 2016-01-20 | — | — | CN | disclosed |