Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 7/20 | 0.60 |
| ▸ | CHRNA4 | P43681 | 7/20 | 0.60 |
| ▸ | CHRNA3 | P32297 | 4/20 | 0.59 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.59 |
| ▸ | CHRNB4 | P30926 | 3/20 | 0.59 |
| ▸ | CHRNA1 | P02708 | 2/20 | 0.59 |
| ▸ | CHRNB1 | P11230 | 2/20 | 0.59 |
| ▸ | CHRNG | P07510 | 1/20 | 0.59 |
| ▸ | CHRND | Q07001 | 1/20 | 0.59 |
| ▸ | IKBKB | O14920 | 2/20 | 0.56 |
| ▸ | CHUK | O15111 | 2/20 | 0.56 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.53 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.53 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.53 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.50 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.50 |
| ▸ | CDC42BPB | Q9Y5S2 | 1/20 | 0.50 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.49 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20038029 | 0.85 | CHRNB2 (0.60) | CHRNB2CHRNA4CHRNA3CHRNA7CHRNB4 | |
| SCHEMBL2240323 | 0.82 | CHRNB2 (0.66) | CHRNB2CHRNA4CHRNA3CHRNA7CHRNB4 | |
| SCHEMBL2267290 | 0.82 | SLC6A2 (0.57) | CHRNB2CHRNA4CHRNA3CHRNB4IKBKB | |
| SCHEMBL3444195 | 0.82 | SLC6A2 (0.57) | CHRNB2CHRNA4CHRNA3CHRNB4IKBKB | |
| SCHEMBL28049595 | 0.82 | CHRNB2 (0.60) | CHRNB2CHRNA4CHRNA3CHRNA7CHRNB4 | |
| Hydrochloric Acid SCHEMBL9555741 | 0.81 | SLC6A2 (0.56) | CHRNB2CHRNA4CHRNA3CHRNB4IKBKB | |
| SCHEMBL10280025 | 0.80 | CHRNB2 (0.66) | CHRNB2CHRNA4CHRNA3CHRNA7CHRNB4 | |
| SCHEMBL31680951 | 0.80 | CHRNB2 (0.66) | CHRNB2CHRNA4CHRNA3CHRNA7CHRNB4 | |
| SCHEMBL12192922 | 0.79 | ROCK1 (0.64) | IKBKBCHUKROCK2ROCK1CDC42BPB | |
| SCHEMBL14346749 | 0.79 | CHRNB2 (0.69) | CHRNB2CHRNA4CHRNA3CHRNA7CHRNB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2417124-B1 | Serotonin and norepinephrine reuptake inhibitor | LILLY CO ELI (US) | 2013-12-18 | — | — | EP | disclosed |
| US-8173821-B2 | Serotonin and norepinephrine reuptake inhibitor | ELI LILLY AND COMPANY (US) | 2012-05-08 | — | — | US | disclosed |
| EP-2417124-A2 | SEROTONIN AND NOREPINEPHRINE REUPTAKE INHIBITOR | Eli Lilly and Company (US) | 2012-02-15 | — | — | EP | disclosed |
| WO-2010117979-A2 | SEROTONIN AND NOREPINEPHRINE REUPTAKE INHIBITOR | ELI LILLY AND COMPANY (US) | 2010-10-14 | — | — | WO | disclosed |
| US-20100261762-A1 | SEROTONIN AND NOREPINEPHRINE REUPTAKE INHIBITOR | ELI LILLY AND COMPANY (US) | 2010-10-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100261762-A1 | SEROTONIN AND NOREPINEPHRINE REUPTAKE INHIBITOR | SLC6A2, SLC6A4, TPH1 | CHRNB2 73/4885CHRNA4 81/4885CHRNA3 89/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.