Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.58 |
| ▸ | LMNA | P02545 | 6/20 | 0.57 |
| ▸ | TSHR | P16473 | 4/20 | 0.57 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 7/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.53 |
| ▸ | MEN1 | O00255 | 4/20 | 0.53 |
| ▸ | JAK2 | O60674 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.51 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.50 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28059516 | 0.92 | KMT2A (0.53) | KMT2ALMNATSHRHTTNPSR1 | |
| SCHEMBL28051054 | 0.85 | MAPT (0.67) | KMT2ALMNATSHRNPSR1SMN1; SMN2 | |
| SCHEMBL27631130 | 0.84 | ALDH1A1 (0.56) | KMT2ALMNATSHRHTTNPSR1 | |
| SCHEMBL27651554 | 0.84 | MEN1 (0.53) | KMT2ALMNAHTTSMN1; SMN2MAPT | |
| SCHEMBL23148487 | 0.81 | MAPT (0.61) | KMT2ALMNATSHRHTTSMN1; SMN2 | |
| SCHEMBL28051140 | 0.80 | MAPT (0.64) | KMT2ALMNATSHRHTTNPSR1 | |
| SCHEMBL29643325 | 0.76 | MAPT (0.68) | KMT2ALMNAHTTNPSR1SMN1; SMN2 | |
| SCHEMBL15466317 | 0.76 | MAPT (0.68) | KMT2ALMNAHTTNPSR1SMN1; SMN2 | |
| SCHEMBL28297104 | 0.76 | KMT2A (0.62) | KMT2ALMNATSHRHTTNPSR1 | |
| SCHEMBL9927442 | 0.76 | KMT2A (0.78) | KMT2ALMNATSHRHTTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105287388-B | High dispersive carbazole sulfonamide derivative and preparation method thereof | 山西普德药业有限公司 | 2019-09-17 | — | — | CN | claimed |
| CN-105418487-B | Carbazole sulfonamide derivative eutectic and preparation method thereof | 山西普德药业有限公司 | 2018-11-02 | — | — | CN | claimed |
| CN-105418487-A | Carbazole sulfonamide derivative eutectic and preparation method thereof | SHANXI PUDE PHARMACEUTICS CO LTD | 2016-03-23 | — | — | CN | claimed |
| CN-105287388-A | High-dispersion carbazole sulfonamide derivatives and preparation method thereof | SHANXI PUDE PHARMACEUTICS CO LTD | 2016-02-03 | — | — | CN | claimed |
| CN-105287388-B | High dispersive carbazole sulfonamide derivative and preparation method thereof | 山西普德药业有限公司 | 2019-09-17 | — | — | CN | disclosed |
| CN-105418487-B | Carbazole sulfonamide derivative eutectic and preparation method thereof | 山西普德药业有限公司 | 2018-11-02 | — | — | CN | disclosed |
| CN-105418487-A | Carbazole sulfonamide derivative eutectic and preparation method thereof | SHANXI PUDE PHARMACEUTICS CO LTD | 2016-03-23 | — | — | CN | disclosed |
| CN-105287388-A | High-dispersion carbazole sulfonamide derivatives and preparation method thereof | SHANXI PUDE PHARMACEUTICS CO LTD | 2016-02-03 | — | — | CN | disclosed |